{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:18:04Z","timestamp":1780579084289,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,9,7]],"date-time":"2007-09-07T00:00:00Z","timestamp":1189123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> Toenail manifestations of chronic venous insufficiency (CVI) may often mimic the nail changes of onychomycosis. The current study aims to determine the frequency of toenails deformations in patients with CVI, onychomycosis prevalence among deformed toenails and the outcome of itraconazole treatment.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> Patients with clinical evidence of (CVI) were enrolled. All patients with toenails deformations and proven onychomycosis were treated by itraconazole pulse therapy for 4\u00a0months and then followed\u2010up for additional 5 to 6\u00a0months.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Forty\u2010four patients with CVI entered the study. Thirty\u2010seven patients (84%) had nail deformations; 28 of 37 patients (75%) had onychomycosis; and 24 patients completed the follow\u2010up period. Total cure was achieved in 6 of 24 patients (25%), and 14 patients (58%) had no improvement. Patients\u2019 age and CVI duration were significantly correlated to onychomycosis cure rate.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Nail deformations are more prevalent in CVI patients (84%) then in the general elderly population, and 75% of affected nails had also onychomycosis. In these patients, itraconazole achieved only 25% total cure rate compared with the 60% to 70% cure rate commonly cited in the literature, probably due to irreversible nail deformity caused by the CVI and due to the thickened nail that prevented penetrance of itraconazole into the nail plate. Therefore, before antifungal treatment is started for onychomycosis in patients with CVI, especially in older patients, the caregiver must stress out that the final outcome might not be as desirable as in pure onychomycosis patients.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02401.x","type":"journal-article","created":{"date-parts":[[2007,9,8]],"date-time":"2007-09-08T16:18:21Z","timestamp":1189268301000},"page":"279-282","source":"Crossref","is-referenced-by-count":21,"title":["Toenail abnormalities and onychomycosis in chronic venous insufficiency of the legs: should we treat?"],"prefix":"10.1111","volume":"22","author":[{"given":"A","family":"Shemer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Nathansohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Trau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.415"},{"key":"e_1_2_5_3_2","first-page":"65","article-title":"Nail changes in cutaneous disease","volume":"10","author":"Kvedar JC","year":"1991","journal-title":"Semin Dermatol"},{"key":"e_1_2_5_4_2","first-page":"309","article-title":"Nail manifestations of systemic diseases","volume":"12","author":"Herzberg AJ","year":"1995","journal-title":"Clin Podiatr Med Surg"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1201\/b14710"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.149.s65.5.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2000.00124.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200405040-00003"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.00181.x"},{"key":"e_1_2_5_10_2","first-page":"183","volume-title":"Diseases of the Nails and Their Management","author":"Tosti A","year":"1994"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331970205300201"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7967(02)70010-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.111633"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051640"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2007.02401.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2007.02401.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T14:54:33Z","timestamp":1697036073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2007.02401.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,7]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1111\/j.1468-3083.2007.02401.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2007.02401.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,7]]}}}