{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:24:26Z","timestamp":1775856266978,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T00:00:00Z","timestamp":1192665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> MAS064D (Sebclair<jats:sup>\u00ae<\/jats:sup>) is a novel steroid\u2010free cream containing multiple active ingredients. Objective of this pilot study was to evaluate the efficacy and safety of MAS064D in the treatment of mild to moderate SD of the face.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a060) with SD were randomized to receive MAS064D (<jats:italic>n<\/jats:italic>\u00a0=\u00a040) or a matching vehicle (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). The primary study endpoint was investigators\u2019 global assessment (IGA) score at day 28, compared with baseline. Secondary endpoints included: IGA score at day 14; investigators\u2019 assessment of erythema and scaling; patients\u2019 assessment of burning\/stinging, pruritus and global response to MAS064D; resort to rescue medication; quality of life.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Use of MAS064D for 4 weeks was associated with a higher percentage of success in the MAS064D group than in the vehicle group (~68% vs 11%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The effects of MAS064D were significantly better than those of vehicle for investigator\u2010assessed erythema and scaling, and patients\u2019 assessed pruritus and global response to MAS064D (<jats:italic>P<\/jats:italic>\u00a0\u00a00.01). No patient in the MAS064D group required rescue medication, compared with two patients in the vehicle group. Four patients (two each in the MAS064D and vehicle groups) reported a total of six non\u2010serious adverse events.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> MAS064D appears to be an effective and well tolerated cream for the treatment of mild to moderate SD of the face. Further clinical evaluation of MAS064D in SD is warranted.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02404.x","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T12:01:15Z","timestamp":1192708875000},"page":"290-296","source":"Crossref","is-referenced-by-count":23,"title":["Treatment of mild to moderate seborrhoeic dermatitis with MAS064D (Sebclair\u00ae), a novel topical medical device: results of a pilot, randomized, double\u2010blind, controlled trial"],"prefix":"10.1111","volume":"22","author":[{"given":"S","family":"Veraldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Menter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Innocenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(03)00028-7"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1997.d01-231.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.9.3350-3357.2002"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410022276"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04082.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02505250"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006811704850"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02362.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630410032430"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05383.x"},{"key":"e_1_2_5_12_2","first-page":"207","article-title":"Pimecrolimus: a new treatment for seborrheic dermatitis","volume":"70","author":"Crutchfield CE III","year":"2002","journal-title":"Cutis"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.7.923"},{"key":"e_1_2_5_14_2","first-page":"29","article-title":"Anti\u2010inflammatory activity of 18\u2010\u03b2\u2010glycyrrhetinic acid in Phytosome\u00ae form","volume":"60","author":"Bombardelli E","year":"1989","journal-title":"Fitoterapia"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92633-S"},{"key":"e_1_2_5_16_2","first-page":"21","article-title":"Malassezia furfur: a fungus belonging to the physiological skin flora and its relevance in skin disorders","volume":"59","author":"Schmidt A.","year":"1997","journal-title":"Cutis"},{"key":"e_1_2_5_17_2","first-page":"442","article-title":"In vitro susceptibility of Malassezia furfur","volume":"46","author":"Schmidt A","year":"1996","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2005.11.521"},{"key":"e_1_2_5_19_2","first-page":"592","article-title":"Free radicals scavenging action and anti\u2010enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action","volume":"44","author":"Maffei Facino R","year":"1994","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_5_20_2","first-page":"129","article-title":"Telmesteine","volume":"29","author":"Hopkins SJ","year":"1993","journal-title":"Drugs Today"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132446"},{"key":"e_1_2_5_22_2","first-page":"67","article-title":"Un nuovo farmaco mucoattivo con attivit\u00e0 anti\u2010proteasica: la telmesteina","volume":"12","author":"Grassi L","year":"1992","journal-title":"Riv Ital Biol Med"},{"key":"e_1_2_5_23_2","first-page":"S207","article-title":"Enhanced delivery of an anti\u2010dandruff active in a shampoo vehicle","volume":"55","author":"Georgalas A.","year":"2004","journal-title":"J Cosmet Sci"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063382"},{"key":"e_1_2_5_25_2","first-page":"172","article-title":"Oral itraconazole for the treatment of seborrhoeic dermatitis: an open, noncomparative trial","volume":"19","author":"Kose O","year":"2005","journal-title":"JEADV"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02123.x"},{"key":"e_1_2_5_27_2","unstructured":"Food & Drug Administration Synopsis of Agents Generally Regarded as Safe.http:\/\/www.cfsan.fda.gov\/~rdb\/opa\u2010gras.html."}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2007.02404.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2007.02404.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T14:54:46Z","timestamp":1697036086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2007.02404.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,18]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1111\/j.1468-3083.2007.02404.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2007.02404.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,18]]}}}