{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T03:05:13Z","timestamp":1788145513148,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T00:00:00Z","timestamp":1192665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Several studies on hair removal with intense pulsed light (IPL) and various laser sources have been done, but adequate data on long\u2010term follow up are scarce. The present uncontrolled prospective pilot study evaluated safety and long\u2010term efficacy of variable pulsed light (VPL\u2122) on hair removal in the face for medical and\/or cosmetic indications.<\/jats:p><jats:p><jats:bold>Study design\/material and methods\u2002<\/jats:bold> The VPL\u2122 system (Energist Ltd, UK) was used for the treatment of hypertrichosis in the face, mainly hirsutism, in 77 female volunteers. The minimum follow\u2010up time after the last treatment was 9\u00a0months (mean: 12.74\u00a0\u00b1\u00a02.87\u00a0months).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Over 50% of hair clearance was observed in 68 (88.3%) of all cases.<\/jats:p><jats:p>Erythema and leucotrichia were the most often associated side\u2010effects encountered. Transient pigmentary changes were not reported.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The VPL\u2122 System presents as a relatively efficient and safe treatment alternative for long\u2010term removal of unwanted hair. It seems to be particularly effective in fair\u2010skinned patients with dark hair (skin types II\u2013III\u2013IV). Adverse effects were minimal and transient and, in no patient, significant enough to interrupt treatment.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02408.x","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T12:01:15Z","timestamp":1192708875000},"page":"311-315","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of safety and efficacy of variable pulsed light in the treatment of unwanted hair in 77 volunteers"],"prefix":"10.1111","volume":"22","author":[{"given":"H","family":"Nahavandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Holzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Knobler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,18]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"319","article-title":"Physical methods for the management of hirsutismus","volume":"45","author":"Wagner RF","year":"1990","journal-title":"Cutis"},{"key":"e_1_2_6_3_2","unstructured":"AltmanDJ HuberF SchrodeKet\u00a0al.Randomized double blind vehicle controlled safety and efficacy evaluation of eflornithine 15% cream in the treatment of women. Poster presented at the 58th Annual meeting of the AAD. San Francisco USA 2000."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90746-8"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10145"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(03)00052-4"},{"key":"e_1_2_6_8_2","first-page":"61","volume-title":"Laser and Lights","author":"Dierickx CC","year":"2005"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70043-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.582"},{"key":"e_1_2_6_11_2","volume-title":"Laser Hair Removal UK","author":"Goldberg DJ","year":"2000"},{"key":"e_1_2_6_12_2","unstructured":"DierickxCC.Hair removal by Lasers and intense pulsed light sources. In:FitzpatrickRE GoldmanMP eds.Cosmetic Laser Surgery USA2000: Mosby176\u2013197."},{"key":"e_1_2_6_13_2","first-page":"128","article-title":"Hair removal with a non\u2010coherent filtered flashlamp intense pulsed light source Laser Surg","volume":"24","author":"Weiss RA","year":"1999","journal-title":"Medical"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.6.668"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.11.1336"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630310004171"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01327.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2007.02408.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2007.02408.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T14:55:03Z","timestamp":1697036103000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2007.02408.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,18]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1111\/j.1468-3083.2007.02408.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2007.02408.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,18]]}}}