{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:59:33Z","timestamp":1791910773276,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T00:00:00Z","timestamp":1193616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose\u2002<\/jats:bold> To evaluate the possible role of stress before the onset\/extension of lichen planus.<\/jats:p><jats:p><jats:bold>Patients and method\u2002<\/jats:bold> Forty\u2010six outpatients with lichen planus were enrolled. The design was a case\u2010control study (controls had skin diseases with low psychosomatic component). Stressful situations were evaluated using Holmes and Rahe's social readjustment rating scale.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Lichen planus had an incidence of 0.36% among dermatological conditions. In the lichen planus group, there was a female predominance (76%) and a median age around 50\u00a0years. More than 67% of cases experienced at least one stressful event, compared with 21% of controls (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a017.58, <jats:italic>P<\/jats:italic>\u00a0&lt; 0.001). The odds ratio was 7.44. There was a borderline significant difference in the mean number of stressful events between lichen planus patients and controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.06). We divided the situations described by Holmes and Rahe into three categories: family, personal, and job or financial problems. The presence of major life events was significant different in patients and controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). Family matters were described by 43.6% of lichen planus patients, statistically significant compared with controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). In almost 25% of cases of lichen planus, \u2018the stressful event\u2019 was represented by the illness or death of someone dear. \u2018Personal problems\u2019 seemed to be important compared with controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), exams representing 25% of these matters. There was no difference between the patients and controls regarding the importance of job or financial changes.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Stressful situations, especially related to family, may have a role in the onset and extension of lichen planus lesions.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02458.x","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T10:16:02Z","timestamp":1193652962000},"page":"437-441","source":"Crossref","is-referenced-by-count":60,"title":["Lichen planus patients and stressful events"],"prefix":"10.1111","volume":"22","author":[{"given":"L","family":"Manolache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Seceleanu\u2010Petrescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Benea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2000.tb02232.x"},{"key":"e_1_2_7_3_2","first-page":"245","article-title":"Skin diseases seen in Kazanchis health center","volume":"36","author":"Hiletework M.","year":"1998","journal-title":"Ethiop Med J"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268805004425"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000056237"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000081157"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90201-X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90205-0"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051777"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1995.tb01181.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2004.tb00072.x"},{"key":"e_1_2_7_12_2","first-page":"1","article-title":"Association between psychological disorders and the presence of oral lichen planus, burning mouth syndrome and recurrent aphtous stomatitis","volume":"9","author":"Soto Araya M","year":"2004","journal-title":"Med Oral"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2003.00960.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01559.x"},{"key":"e_1_2_7_15_2","first-page":"265","article-title":"The psychopathological aspects of oral lichen planus","volume":"42","author":"Colella G","year":"1993","journal-title":"Minerva Stomatol"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00829.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1996.0277"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016359509005979"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(67)90010-4"},{"key":"e_1_2_7_20_2","volume-title":"Anxiety and Stress Management","author":"Powell TJ","year":"1990"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000069731"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.44.5.374"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.46.6.556"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2007.02458.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2007.02458.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:18:19Z","timestamp":1697037499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2007.02458.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,29]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1111\/j.1468-3083.2007.02458.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2007.02458.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,29]]}}}