{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:35:47Z","timestamp":1793367347870,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T00:00:00Z","timestamp":1195603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> Pimecrolimus is a calcineurin inhibitor used for the topical treatment of inflammatory skin diseases. We have shown previously that pimecrolimus cream is not effective on intact skin in the ultraviolet erythema test.<\/jats:p><jats:p><jats:bold>Objective\u2003<\/jats:bold> To test the anti\u2010inflammatory effect of pimecrolimus cream after damage of the skin barrier by sodium lauryl sulphate (SLS) in a randomised, placebo\u2010controlled, observer\u2010blinded study.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> SLS (3% v\/v) was applied under occlusion on the back of 36 healthy volunteers for 24\u00a0h. Subsequently, the test areas were treated for 24\u00a0h with pimecrolimus cream, 1% hydrocortisone in a hydrophilic ointment, and the vehicle alone over three consecutive days. One control area remained untreated. The erythema index and the transepidermal water loss (TEWL) served as readout parameters to assess the SLS\u2010induced skin irritation.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Pimecrolimus cream and 1% hydrocortisone cream significantly reduced the SLS\u2010induced erythema. The two test preparations did not have a significant effect on the TEWL.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> After damage to the skin barrier by SLS, pimecrolimus seems to penetrate into the skin as shown by a reduction of the irritation\u2010induced erythma. These data further support the notion that pimecrolimus is selectively effective in the treatment of skin disorders with an impaired function of the epidermal barrier.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02477.x","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T19:37:19Z","timestamp":1195673839000},"page":"447-450","source":"Crossref","is-referenced-by-count":29,"title":["Anti\u2010inflammatory effect of pimecrolimus in the sodium lauryl sulphate test"],"prefix":"10.1111","volume":"22","author":[{"given":"K","family":"Engel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Seiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Schulte","family":"M\u00f6nting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Jakob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CM","family":"Schempp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.122187"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.00269.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38376.439653.D3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630510033159"},{"key":"e_1_2_6_6_2","first-page":"385","article-title":"Therapie des atopischen Ekzems mit Calcineurin\u2010Inhibitoren","volume":"5","author":"Luger TA","year":"2005","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.999"},{"key":"e_1_2_6_8_2","first-page":"41","article-title":"Adverse effects from topical steroids","volume":"1","author":"Hill C","year":"1978","journal-title":"Cutis"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000086669"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2003.07.013"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050516"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03507.x"},{"key":"e_1_2_6_13_2","first-page":"659","article-title":"Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. 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