{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:40:23Z","timestamp":1791229223317,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> In recent studies, it has been documented that the eosinophil cells play active role in many kinds of inflammatory disorders. Measurements of the mediators released by eosinophils and cell counts in serum and skin have provided some evidence indicating the role of eosinophils in psoriasis.<\/jats:p><jats:p><jats:bold>Objective\u2003<\/jats:bold> To evaluate the blood eosinophil cell count in patients with erythrodermic psoriasis and generalized pustular psoriasis.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> In this study, 48 patients with histopathologically proven psoriasis (33 with erythrodermic, 15 with generalized pustular); 43 patients with maculopapular, erythematous, or bullous drug eruption with widespread involvement; and 51 patients with basal cell carcinoma were included. These three groups were compared with each other in terms of their absolute eosinophil cell counts and percentage of eosinophils.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> Forty\u2010one point seven per cent of patients with psoriasis had peripheral blood eosinophilia compared with 58.1% of the patients with drug eruption and 11.8% of patients with basal cell carcinoma. The percentage of patients with eosinophilia both in patients suffering from psoriasis and drug eruption were significantly increased compared with the patients with basal cell carcinoma (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.001). The absolute median eosinophil cell counts both in patients with psoriasis and drug eruption were also significantly differed from patients with basal cell carcinoma (259.2, 439.1 and 183.1, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001)<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Peripheral blood eosinophilia seems to be associated with severe forms of psoriasis. This finding may suggest that the eosinophils have significant roles in the pathogenesis of these types of psoriasis.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02489.x","type":"journal-article","created":{"date-parts":[[2008,3,19]],"date-time":"2008-03-19T17:41:50Z","timestamp":1205948510000},"page":"451-455","source":"Crossref","is-referenced-by-count":17,"title":["Peripheral blood eosinophilia in association with generalized pustular and erythrodermic psoriasis"],"prefix":"10.1111","volume":"22","author":[{"given":"AT","family":"Mansur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"G\u00f6ktay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eP","family":"Ya\u015far","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01964739"},{"key":"e_1_2_5_3_2","first-page":"99","article-title":"The characteristics of the pathogenesis, course and treatment of psoriasis in younger and older patients","volume":"2","author":"Trunina TI","year":"1999","journal-title":"Lik Sprava"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.1999.03.638"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01566.x"},{"key":"e_1_2_5_6_2","first-page":"495","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Christophers E","year":"1999"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(97)00614-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2340\/0001555571495501","article-title":"Eosinophilic cationic protein (ECP) in skin disorders","volume":"71","author":"Juhlin L","year":"1991","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247447"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00975.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00557966"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382206"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050573"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb08264.x"},{"key":"e_1_2_5_15_2","first-page":"785","volume-title":"Williams Hematology","author":"Wardlaw AJ","year":"2001"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06038.x"},{"key":"e_1_2_5_17_2","first-page":"281","article-title":"Clinical reference values for laboratory hematology tests calculated using the iterative truncation method with correction: part 2, reference values for white blood cell (WBC) count, WBC differential including segmented neutrophil, band neutrophil, lymphocyte, monocyte, eosinophil, basophil, platelet count and mean platelet Volume","volume":"47","author":"Shiga S","year":"1999","journal-title":"Rinsho Byori"},{"key":"e_1_2_5_18_2","first-page":"963","article-title":"Eosinophilia detected by automated blood cell counting in ambulatory North American outpatients. 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