{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:42:10Z","timestamp":1784191330782,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T00:00:00Z","timestamp":1199923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> Onychomycosis is a rare disease in children with an estimated prevalence ranging from 0% to 2.6%. Thus far, only limited experience with itraconazole and terbinafine treatment in children with onychomycosis is available in the literature.<\/jats:p><jats:p><jats:bold>Aim of the study\u2003<\/jats:bold> Evaluation of treatment experience with itraconazole or terbinafine in childhood onychomycosis.<\/jats:p><jats:p><jats:bold>Subjects\u2003<\/jats:bold> Thirty\u2010six children and adolescents (aged 4\u201317\u00a0years, 18 males and 18 females) with clinical and mycologically proven onychomycosis were enrolled in the present study.<\/jats:p><jats:p><jats:bold>Methods and outcome\u2003<\/jats:bold> In 27 of 36 patients, the causative agent (<jats:italic>Trichophyton rubrum<\/jats:italic> in 26 cases and <jats:italic>Trichophyton interdigitale<\/jats:italic> in one patient) could be identified by means of cultivation. Nineteen patients were treated with itraconazole 200\u00a0mg once daily for 12\u00a0weeks, and 17 patients were treated with terbinafine for 12\u00a0weeks in a dosage according to their body weight, respectively. Clinical cure was achieved within 1 to 5\u00a0months after discontinuation in all patients treated with itraconazole and in all but two patients after cessation of terbinafine treatment. Neither in the itraconazole nor in the terbinafine group were serious adverse events reported.Clinical cure was achieved within 1 to 5\u00a0months after discontinuation in all patients treated with itraconazole and in all but two patients after cessation of terbinafine treatment. Neither in the itraconazole nor in the terbinafine group were serious adverse events reported.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> To our experience, a mycological and clinical cure appears in children in a shorter time after treatment discontinuation (average 2\u20135\u00a0months) compared with adults. Itraconazole and terbinafine seem to be safe and effective in childhood onychomycosis; therefore, these antifungals seem to be potential alternatives to griseofulvin.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02498.x","type":"journal-article","created":{"date-parts":[[2008,3,19]],"date-time":"2008-03-19T17:41:50Z","timestamp":1205948510000},"page":"470-475","source":"Crossref","is-referenced-by-count":36,"title":["Onychomycosis: a new emerging infectious disease in childhood population and adolescents. Report on treatment experience with terbinafine and itraconazole in 36 patients"],"prefix":"10.1111","volume":"22","author":[{"given":"G","family":"Ginter\u2010Hanselmayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Weger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Smolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)80142-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb15651.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70167-G"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s102270000021"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199408000-00014"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80215-0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1989.tb00932.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2005.01186.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01631.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01802.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21117.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70321-9"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.06133.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00182.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.6.614"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1998.tb01396.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81838-5"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb00711.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70025-8"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.691"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1996.tb00732.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2007.02498.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2007.02498.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:17:21Z","timestamp":1697037441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2007.02498.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,10]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1111\/j.1468-3083.2007.02498.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2007.02498.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,10]]}}}