{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:05:41Z","timestamp":1779167141324,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T00:00:00Z","timestamp":1199923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background\u2002Iron accumulation as seen in genetic haemochromatosis is a major cause of hepatic fibrogenesis. A link between chronic liver disease and Dupuytren's disease (DD) is well established, especially in alcoholics.<\/jats:p><jats:p><jats:bold>Aim\u2003<\/jats:bold> The aim of the present study was to test the hypothesis that iron accumulation might cause fibrosis of the palmar aponeurosis leading to DD.<\/jats:p><jats:p><jats:bold>Patients and methods\u2003<\/jats:bold> We examined iron metabolism, mutations of the <jats:italic>HFE<\/jats:italic> gene, serum cholesterol, alcohol consumption, presence of chronic liver disease, diabetes and history of severe manual work in a group of 90 patients who had undergone surgery for a severe form of DD. The tissue removed during surgery was histologically examined to confirm the diagnosis of DD. For a control group, we used 33 healthy subjects with similar profiles.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> The DD group consisted of 82 men and 8 women. Chronic liver disease was found in 27% of DD patients, compared with 6.1% of control subjects (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.013). A history of hand traumatization was present in 33% of DD patients vs. 15% of control subjects (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.048). Excessive alcohol consumption was present in 35.5% of DD patients compared with 15.1% of controls (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.029). None of the other tested parameters, including the prevalence of <jats:italic>HFE<\/jats:italic> gene mutations, showed a significant difference between the two groups.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Iron accumulation does not play a major role in the pathogenesis of DD. However, sex, age, manual labour and alcohol consumption are risk factors for progression of DD. We observed a high incidence of chronic liver disease in patients with DD.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02506.x","type":"journal-article","created":{"date-parts":[[2008,3,19]],"date-time":"2008-03-19T17:41:50Z","timestamp":1205948510000},"page":"476-480","source":"Crossref","is-referenced-by-count":8,"title":["Lack of association of iron metabolism and Dupuytren's disease"],"prefix":"10.1111","volume":"22","author":[{"given":"J","family":"Hnanicek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cimburova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Putova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Svoboda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Stritesky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kratka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Sosna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Horak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,10]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"311","volume-title":"Iron Metabolism in Health and Disease","author":"Brock JH","year":"1994"},{"key":"e_1_2_6_3_2","first-page":"1261","volume-title":"Gastrointestinal and Liver Disease","author":"Feldman M","year":"2002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00145-6"},{"key":"e_1_2_6_5_2","unstructured":"JamesDS GrothausPC.Dupuytren's disease: an overview.Plast. 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Detection of C282Y and H63D mutations in HFE gene by means of Guthrie cards in population of Czech Republic","volume":"23","author":"Cimburova M","year":"2002","journal-title":"General Epidem"},{"key":"e_1_2_6_8_2","first-page":"172","article-title":"S65C and other mutations in the haemochromatosis gene in the Czech population","volume":"51","author":"Cimburova M","year":"2005","journal-title":"Folia Biol (Praha)"},{"key":"e_1_2_6_9_2","first-page":"1375","volume-title":"Gastrointestinal and Liver Disease","author":"Feldman M","year":"2002"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-399"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(03)00176-0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","unstructured":"GudmundssonGK ArngrimssonR JonssonT.Dupuytren's disease alcohol consumption and alcoholism.Scand. J. Prim. 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