{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:08:55Z","timestamp":1790111335982,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T00:00:00Z","timestamp":1199923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Pemphigus vulgaris can be divided into mucosal, mucocutaneous and cutaneous subtypes. A higher mortality rate has been shown with mucocutaneous involvement.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> The aim of this retrospective study was to analyse the association of clinical subtypes of pemphigus vulgaris with remission rates.<\/jats:p><jats:p><jats:bold>Patients\/methods\u2002<\/jats:bold> One hundred twenty\u2010eight patients with pemphigus vulgaris, treated with prednisolone 2\u00a0mg\/kg\/day plus azathioprine 2 to 2.5\u00a0mg\/kg\/day, were enrolled. The partial and complete remission rates, at the end of the first and second years of treatment, and the number of relapses were compared in the three groups.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> After disease establishment, 71.1% had mucocutaneous, 18.8% had mucosal, and 10.2% had only cutaneous involvement. The mean duration of follow\u2010up was 53.5\u00a0\u00b1\u00a039.6\u00a0months.<\/jats:p><jats:p>The mean duration it took the mucocutaneous group to reach a prednisolone dosage of 30\u00a0mg\/day was significantly longer (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.050). Mucocutaneous patients had a significantly lower rate of remission (31.9%) compared with those with only mucosal or cutaneous involvement (48.6%) at the end of the first year of the treatment (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.029). After 2 years, mucocutaneous patients again had a lower remission rate (32.9% vs. 44.5%). Relapses were also more frequent in this subtype.<\/jats:p><jats:p>Those presenting with mucosal or mucocutaneous erosions had a higher rate of active disease after receiving treatment for a year compared with those with only cutaneous presentation (66.7% vs. 45%; <jats:italic>P\u00a0=<\/jats:italic>\u00a00.057).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In mucocutaneous subtype, clinical control was achieved later, and they had a lower rate of remission at the end of the first and second years of treatment. They were also prone to relapses.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2007.02537.x","type":"journal-article","created":{"date-parts":[[2008,4,10]],"date-time":"2008-04-10T03:34:15Z","timestamp":1207798455000},"page":"580-584","source":"Crossref","is-referenced-by-count":20,"title":["Outcome of pemphigus vulgaris"],"prefix":"10.1111","volume":"22","author":[{"given":"S","family":"Kavusi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Daneshpazhooh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Farahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Abedini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Lajevardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Chams\u2010Davatchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.01.106"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70183-0"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.438"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02501.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05665.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2006.03756.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02374.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04132.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088513"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66829-8"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00664.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02533.x"},{"key":"e_1_2_7_14_2","unstructured":"Chams\u2010DavatchiC EsmailiN DaneshpazhoohMet\u00a0al.Randomized controlled open\u2010label trial of four treatment regimens for pemphigus vulgaris.J Am Acad Dermatol2007."},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5359.30749"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01266.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70111-2"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890260105016"},{"key":"e_1_2_7_19_2","first-page":"96","article-title":"[Therapy of pemphigus. 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