{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:23:13Z","timestamp":1772659393416,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T00:00:00Z","timestamp":1209427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Several controversies exist regarding the relationship between hepatitis C virus (HCV) infection and some cutaneous manifestations, lichen planus (LP) in particular.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To determine the prevalence of LP and other cutaneous manifestations in a cohort of patients infected with HCV from low HCV endemic area of Slovenia, to correlate findings with chosen biological variables and to assess the role of interferon (IFN)\u2010based treatment of HCV infection in cutaneous manifestations.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A total of 171 consecutive HCV\u2010seropositive patients and 171 HCV\u2010seronegative age\u2010 and gender\u2010matched controls were studied prospectively. Prevalence of cutaneous manifestations, comparison between study patients and controls and correlation of skin findings with demographic, biochemical, virological and liver histologic findings as well as IFN\u2010based therapy were assessed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Overall presence of LP in HCV\u2010seropositives was 2.3%; although LP was not found in controls, the difference was not statistically significant (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.123). Significantly higher than in controls was the prevalence of pruritus (31.0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), dry skin (16.4%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and hair loss (9.9%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In IFN\u2010based treatment na\u00efves, skin findings were more frequent compared with controls, but not significantly, with no correlation to chosen biological variables. Current IFN\u2010based treatment was significantly connected to pruritus (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.001) and dry skin (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.001). Compared with treatment na\u00efves, in post\u2010treated patients pruritus (odds ratio, 19.13; 95% confidence interval, 6.85\u201353.42; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), dry skin (odds ratio, 4.21; 95% confidence interval, 1.44\u201312.31; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and hair loss (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.001) were significantly more common.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> LP was not significantly related to HCV infection. Prevalence of pruritus, dry skin and hair loss was significantly higher in post\u2010compared with pre\u2010treated patients. The role of IFN in post\u2010treatment persistence of skin manifestations needs to be assessed.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2008.02676.x","type":"journal-article","created":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T18:28:30Z","timestamp":1209493710000},"page":"779-788","source":"Crossref","is-referenced-by-count":28,"title":["Lichen planus and other cutaneous manifestations in chronic hepatitis C: pre\u2010 and post\u2010interferon\u2010based treatment prevalence vary in a cohort of patients from low hepatitis C virus endemic area"],"prefix":"10.1111","volume":"22","author":[{"given":"M","family":"Maticic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Poljak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Lunder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Rener\u2010Sitar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Stojanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,6]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"425","article-title":"Hepatitis C \u2013 global prevalence (up\u2010date)","volume":"74","author":"World Health Organization","year":"1999","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_7_3_2","first-page":"S84","article-title":"Consensus Statement","volume":"30","author":"European Association for the Study of the Liver","year":"1999","journal-title":"J Hepatol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07642-8"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199910)42:10<2204::AID-ANR24>3.0.CO;2-D"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.06.008"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2003.11.010"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.077"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06257.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2001.00695.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.30126"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.11.017"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(97)00067-3"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.10763.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90286-4"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.17936"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155598443051"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1309\/HDWCT36P0GMGP40V"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32821f6134"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840360703"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.06.010"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01710739"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-005-1319-7"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.2.215"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.7.865"},{"key":"e_1_2_7_26_2","first-page":"1320","article-title":"Efficacy of chronic hepatitis C therapy with interferon alpha (IFN\u2010alpha) in Slovenia","volume":"49","author":"Brinovec V","year":"2002","journal-title":"Hepatogastroenterol"},{"key":"e_1_2_7_27_2","first-page":"253","article-title":"High prevalence of hepatitis C virus infection in a southern Italian rural region. 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