{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:59:35Z","timestamp":1780595975370,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T00:00:00Z","timestamp":1231459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> In view of the potentially serious side\u2010effects of standard isotretinoin (0.5\u20131.0\u00a0mg\/kg\u00a0per day) therapy for acne, we studied the safety and efficacy of low\u2010fixed dose isotretinoin plus topical 1%clindamycin gel in the treatment of moderate grade of acne.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In this prospective, non\u2010comparative study, 320 adult patients, with moderately severe acne were enrolled and treated with fixed\u2010dose isotretinoin at 20\u00a0mg every alternate day (approximately 0.15\u00a0mg\/kg\/day to 0.28\u00a0mg\/kg\/day) for 6\u00a0months along with topical clindamycin gel. All female patients were assessed for polycystic ovarian disease. Patients were followed up for 6\u00a0months.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 305 patients completed the study. Overall, patients received a mean of 38.4\u00a0mg\/kg cumulative dose of isotretinoin, and very good results were observed in 208 (68.20%), while good response was seen in 59 (19.34%) of patients. Failure of the treatment occurred in 38 (12.46%), while relapses occurred in 50 (16.39%) of patients. Relapses were commoner in females, and 37 of 43 (86.04%) patients had polycystic ovarian disease. Though mild chelitis (91%) and xerosis (43%) were common, laboratory abnormalities in the form of elevated hepatic enzymes (5%) and elevated serum lipids (6%) were rare.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Six months of treatment with fixed\u2010dose, alternate\u2010day isotretinoin (20\u00a0mg) plus topical 1%clindamycin gel was found to be effective in the treatment of moderate acne in adult patients, with a low incidence of side\u2010effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conflicts of interest<\/jats:title><jats:p>None declared<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-3083.2008.03022.x","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T11:38:12Z","timestamp":1231501092000},"page":"556-560","source":"Crossref","is-referenced-by-count":33,"title":["Efficacy of fixed low\u2010dose isotretinoin (20\u00a0mg, alternate days) with topical clindamycin gel in moderately severe acne vulgaris"],"prefix":"10.1111","volume":"23","author":[{"given":"K","family":"Sardana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VK","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VN","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bhushan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246134"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80076-X"},{"key":"e_1_2_5_4_2","first-page":"47","article-title":"Clinical evaluation in acne","volume":"89","author":"Liden S","year":"1980","journal-title":"Acta Dermatovener (Stockholm)"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.17771864.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02321.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03626.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00763.x"},{"key":"e_1_2_5_9_2","first-page":"41","article-title":"Low\u2010dose schema of isotretinoin in acne vulgaris","volume":"23","author":"Mandekou\u2010Lefaki I","year":"2003","journal-title":"Int J Clin Pharmacol Res"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.11.1061"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00402.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)01154-X"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01784.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000057887"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0353.2004.03739.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2003.00108.x-i1"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00437.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.115965"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0777-2"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2008.03022.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2008.03022.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:10:35Z","timestamp":1697062235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2008.03022.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,3]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1111\/j.1468-3083.2008.03022.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2008.03022.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,3]]}}}