{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:43:35Z","timestamp":1777765415204,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T00:00:00Z","timestamp":1229558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Hyperhomocysteinaemia is a risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. An association between psoriasis and cardiovascular diseases has been reported.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> The aim of our study was to examine serum homocysteine, folic\u00a0acid and vitamin\u00a0B<jats:sub>12<\/jats:sub> levels in psoriasis patients.<\/jats:p><jats:p><jats:bold>Material and methods\u2002<\/jats:bold> We performed a cross\u2010sectional study in 70 consecutive outpatients with chronic plaque psoriasis and 70 age\u2010 and gender\u2010matched controls. Serum levels of homocysteine, vitamin\u00a0B<jats:sub>12<\/jats:sub> and folic\u00a0acid levels were measured in both groups.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Serum homocysteine, folic\u00a0acid and vitamin\u00a0B<jats:sub>12<\/jats:sub> levels did not differ between patient and control groups. In psoriasis patients, homocysteine levels correlated directly with psoriasis severity as measured by psoriasis area and severity index. Serum homocysteine level inversely correlated with serum folic acid levels in the patient group.<\/jats:p><jats:p><jats:bold>Discussion\u2002<\/jats:bold> Homocysteine levels correlated with psoriasis area and severity index in the patient group, which shows the disease severity. The increase in cardiovascular mortality with the severity of psoriasis might be also due to the effects of homocysteine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conflicts of interest<\/jats:title><jats:p>None declared<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-3083.2008.03024.x","type":"journal-article","created":{"date-parts":[[2008,12,20]],"date-time":"2008-12-20T04:53:44Z","timestamp":1229748824000},"page":"300-303","source":"Crossref","is-referenced-by-count":37,"title":["Homocysteine, vitamin\u00a0B<sub>12<\/sub> and folic\u00a0acid levels in psoriasis patients"],"prefix":"10.1111","volume":"23","author":[{"given":"SK","family":"\u00c7akmak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dc","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"G\u00f6n\u00fcl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Soylu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.07.011"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJEP.0000020447.59150.f9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00036-2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331970605700102"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2001.110"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07503.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.179"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(03)00082-2"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2143\/AC.62.6.2024017","article-title":"Effects of folic acid and N\u2010acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease","volume":"62","author":"Y\u0131lmaz H","year":"2007","journal-title":"Acta Cardiol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331970605700102"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91336-X"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(99)00248-8"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/ajcn\/86.5.1563S","article-title":"Homocysteine, vitamins, and vascular disease prevention","volume":"86","author":"McCully KS","year":"2007","journal-title":"Am J Clin Nutr"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2008.03024.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2008.03024.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:57:36Z","timestamp":1696942656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2008.03024.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,9]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1111\/j.1468-3083.2008.03024.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2008.03024.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,9]]}}}