{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:20:08Z","timestamp":1761862808884},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T00:00:00Z","timestamp":1229558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> CD28 superfamily of immune costimulatory molecules could play an important role in autotolerance control. CD28 costimulation seems to be necessary for regulatory T cell (Treg) activation and successive suppressive activities involved in autoimmunity protection. This study investigates CD28 expression, especially inducible costimulator fraction, on T lymphocytes in pemphigus vulgaris (PV) patients.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> CD28 expression on T lymphocytes was assessed in 16 PV patients during acute attack. All patients and 10 healthy control subjects were tested for lymphocyte populations, T\u2010cell subpopulations (T\u2010CD4<jats:sup>+<\/jats:sup>, T\u2010CD8<jats:sup>+<\/jats:sup>), Treg and CD28 expression on T\u2010cell subpopulations.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> T, B and natural killer cells average values in PV patients were close to the control group values. Compared with control group, PV values showed lower Treg (2.2% compared with 4.7%), slightly decreased CD4<jats:sup>+<\/jats:sup>\u00a0CD28<jats:sup>+<\/jats:sup> T cells (91% compared with 95%), higher CD4<jats:sup>+<\/jats:sup>\u00a0CD28<jats:sup>\u2212<\/jats:sup> T cells (9% compared with 5%), decreased CD8<jats:sup>+<\/jats:sup>\u00a0CD28<jats:sup>+<\/jats:sup> T cells (57% and 73%, respectively) and significantly enhanced CD8<jats:sup>+<\/jats:sup> CD28<jats:sup>\u2212<\/jats:sup> T cells (43% compared with 27%).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> These data suggest that Treg\u2010mediated suppressor T\u2010cell effects could be diminished in PV, together with an abnormal or ineffective subsequent helper T\u2010cell suppression. CD28 high expression on helper T cells and low expression on suppressor T cells are arguments for a potential CD28 role in PV autoimmune response mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conflicts of interest<\/jats:title><jats:p>None declared<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-3083.2008.03035.x","type":"journal-article","created":{"date-parts":[[2008,12,20]],"date-time":"2008-12-20T05:56:29Z","timestamp":1229752589000},"page":"288-291","source":"Crossref","is-referenced-by-count":15,"title":["CD28 T\u2010cell costimulatory molecule expression in pemphigus vulgaris"],"prefix":"10.1111","volume":"23","author":[{"given":"M","family":"Alecu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Ursaciuc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Surcel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Coman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Ciotaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Dobre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,9]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"558","volume-title":"Fitzpatrik's Dermatology in General Medicine","author":"Stanley JR","year":"2003"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000024364"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28547"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.5.3215"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00398-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(02)00341-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.7.3348"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1928"},{"key":"e_1_2_5_10_2","first-page":"245","article-title":"Expression of costimulatory molecules B7\/CD28 in systemic lupus erythematosus","volume":"24","author":"Hu S","year":"2006","journal-title":"J Huazhong University Sci Technol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014256417651"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161206775193046"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.11.5421"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011948"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1999.0642"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-004-0528-6"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.2.1526"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-004-0042-3"},{"key":"e_1_2_5_19_2","first-page":"1084","article-title":"Elevation of antigen specific CD8+ CD28\u2212 cells in newly remittent patients with pemphigus vulgaris","volume":"125","author":"Sinha E.","year":"2004","journal-title":"J Invest Dermatol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1596"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2008.03035.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2008.03035.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:58:06Z","timestamp":1696942686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2008.03035.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,9]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1111\/j.1468-3083.2008.03035.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2008.03035.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,9]]}}}