{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:40:16Z","timestamp":1770482416966,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T00:00:00Z","timestamp":1231804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Tacrolimus inhibits T\u2010lymphocyte activation and dermal Langerhans\u2019 cells, without the side\u2010effects of corticosteroids. The safety profile of tacrolimus makes it a promising therapeutic option for dermatitis affecting the delicate periorbital skin.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To access the efficacy and tolerability of tacrolimus ointment 0.1% in the treatment of allergic contact eyelid dermatitis.<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> Twenty adults (16 women, 4 men) with eyelid dermatitis and with at least one positive patch test reaction to relevant contact allergens were treated with topical tacrolimus in a prospective, open\u2010label, non\u2010comparative clinical study. Dermatitis was graded at baseline, at day 30 and day 60, using a 4\u2010point grading system for the following parameters: erythema, oedema, scaling, lichenification, fissuring (investigator assessment) and burning\/stinging and pruritus (patient assessment).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> All patients completed the study. Erythema, oedema, scaling and lichenification showed improvement from baseline to 30\u00a0days of treatment (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.001), but fissuring was not significantly affected. At 60\u00a0days, no further improvement of these investigator parameters was observed. Patient parameters improved significantly by day 30 (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.004) and there was a trend for further improvement at the end of 60\u00a0days (for burning, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.046; for pruritus, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.059). Ten per cent of patients mentioned burning and itching, at the application site, during the first days of treatment. No other adverse events were observed.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Topical tacrolimus is a promising alternative in patients with allergic contact eyelid dermatitis. Therapy was effective by 1\u00a0month and was well tolerated. These preliminary results merit a larger, controlled, study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conflict of interest<\/jats:title><jats:p>This study was not funded by a drug company, and none of the investigators have received financial support\/grants by the makers of the drug tacrolimus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-3083.2008.03056.x","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T15:19:24Z","timestamp":1231859964000},"page":"382-387","source":"Crossref","is-referenced-by-count":27,"title":["Tacrolimus ointment 0.1% in the treatment of allergic contact eyelid dermatitis"],"prefix":"10.1111","volume":"23","author":[{"given":"A","family":"Katsarou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Armenaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Vosynioti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Lagogianni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kalogeromitros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Katsambas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02148.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01634989-200306000-00004"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000422371"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018495"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2004.00787.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.109816"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112600"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90111-J"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.0217.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00920.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1986.tb01229.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb05242.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.0548i.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01610.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102060-00005"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2638"},{"key":"e_1_2_5_18_2","first-page":"267","article-title":"Tacrolimus ointment in the treatment of eyelid dermatitis","volume":"73","author":"Freeman AK","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91757-Y"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)01826-7"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00664.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2006.27.2915"},{"key":"e_1_2_5_23_2","first-page":"225","article-title":"Topical macrolactams: new indications, potential pitfalls. 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