{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:54:22Z","timestamp":1789016062777,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T00:00:00Z","timestamp":1237420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:sec><jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Acute and chronic graft\u2010versus\u2010host disease (GVHD) continues to be a major limitation to successful haematopoietic stem cell transplantation. If experimental studies and clinical observations could partially elucidate the pathophysiology of acute GVHD, the biology of chronic GVHD is still much less well understood.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> The aim of this study is to describe a peculiar photoinduced rash which triggered acute and then chronic lesions of GVHD in four allogenic haematopoietic\u2010transplated patients and discuss the possible aetiology and treatment.<\/jats:p><jats:p><jats:bold>Patients\/methods\u2002<\/jats:bold> Four patients, two children and two adults affected by either mild or severe chronic GVHD, developed an erythematous rash on sun\u2010 or narrow\u2010band ultraviolet B\u2010exposed area, which triggered the onset of acute lesions of GVHD. Any of the patients presented neither a history of photosensitivity nor circulating autoantibodies nor urinary\/fecal porphyrine.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The histopathologic findings were characterized by an interface dermatitis with sparse perivascular infiltrate of lymphocytes and scattered necrotic keratinocytes, especially in the upper part of epidermis. Direct immunofluorescence studies excluded lupus\u2010like pattern, revealing nests of fluorescent bodies at the dermal\u2013epidermal junction and in papillary dermis.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> This peculiar isomorphic reaction of cutaneous GVHD after sun or narrow\u2010band ultraviolet B exposures is described, and the possible mechanism involved is discussed. It may represent an interesting model of progression of chronic GVHD, starting with an acute stage and ending up with chronic clinical and histological findings, especially considering that there is no animal model that fully replicates all of the features of chronic GVHD in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conflicts of interest<\/jats:title><jats:p>None declared.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1468-3083.2009.03220.x","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T13:56:08Z","timestamp":1237470968000},"page":"913-918","source":"Crossref","is-referenced-by-count":12,"title":["Isomorphic cutaneous graft\u2010versus\u2010host disease reaction after ultraviolet exposure: clinical, histological and direct immunofluorescence studies of four allo\u2010transplanted patients"],"prefix":"10.1111","volume":"23","author":[{"given":"C","family":"Vassallo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Brazzelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Zecca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PE","family":"Alessandrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Borroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,6]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"245","volume-title":"Graft\u2010Vs.\u2010Host Disease","author":"Volc\u2010Platzer B","year":"1990"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702530"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2002.v8.pm11858190"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.2.406"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1182\/blood.V80.7.1838.1838","article-title":"Acute GvHD: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate","volume":"80","author":"Nash RA","year":"1991","journal-title":"Blood"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666080-00002"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000183878.53367.77"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2006.09.001"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.10.023"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701460"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0248-8663(96)80871-X"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.45"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247209"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00641.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.4049\/jimmunol.120.5.1485","article-title":"Deposition of IgM and complement at the dermoepidermal junction in acute and chronic cutaneous graft\u2010vs.\u2010host disease in man","volume":"120","author":"Tsoi MS","year":"1978","journal-title":"J Immunol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1991.tb03091.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1997.tb01107.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/archderm.1983.01650320057018","article-title":"Graft\u2010vs.\u2010host disease","volume":"119","author":"James WD","year":"1983","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/archderm.1997.03890440027003","article-title":"Lichen planus\u2010like histopathologic characteristics in the cutaneous graft\u2010vs\u2010host reaction. 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