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The existence of comorbid conditions and potential for drug\u2013drug interactions complicates the selection of an appropriate treatment regimen. The role of<jats:italic>Candida<\/jats:italic>in onychomycosis is controversial but may be of increased significance in the diabetic population due to an underlying vulnerability to this organism.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Terbinafine is an excellent choice in diabetics due to its low risk of drug\u2013drug interaction and proven efficacy against the typical pathogens that cause onychomycosis. Itraconazole, while an effective treatment for onychomycosis, is not a first\u2010choice therapy due to its black\u2010box cardiac warning and numerous drug interactions. Larger studies are needed in diabetics to determine the frequency of candidal nail infections.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2009.03225.x","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T10:00:39Z","timestamp":1236333639000},"page":"1119-1122","source":"Crossref","is-referenced-by-count":46,"title":["Onychomycosis and diabetes"],"prefix":"10.1111","volume":"23","author":[{"given":"S","family":"Cathcart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Cantrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BE","family":"Elewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,9,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02464.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03606.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01534.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.04.004"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2031"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.110376"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.415"},{"key":"e_1_2_7_9_2","unstructured":"JanesGR.Ambulatory medical care for diabetics. 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