{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:44:32Z","timestamp":1789969472199,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T00:00:00Z","timestamp":1239148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Backround\u2002<\/jats:bold> Pemphigus vulgaris is a rare chronic autoimmune disease of skin and mucous membranes, with several cytokines participating in its development. The role of their gene polymorphisms in susceptibility to the disease is, however, not fully understood.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> The aim of our case\u2010control study was to investigate whether some of 22 single nucleotide polymorphisms (SNPs) in 13 cytokine genes (<jats:italic>IL\u20101\u03b1<\/jats:italic>, <jats:italic>IL\u20101\u03b2<\/jats:italic>, <jats:italic>IL\u20101RI<\/jats:italic>, <jats:italic>IL\u20101Ra<\/jats:italic>, <jats:italic>IL\u20104R\u03b1<\/jats:italic>, <jats:italic>IL\u201012<\/jats:italic>, <jats:italic>IFN\u2010\u03b3<\/jats:italic>, <jats:italic>TGF\u2010\u03b21<\/jats:italic>, <jats:italic>TNF\u2010\u03b1<\/jats:italic>, <jats:italic>IL\u20102<\/jats:italic>, <jats:italic>IL\u20104<\/jats:italic>, <jats:italic>IL\u20106<\/jats:italic> and <jats:italic>IL\u201010<\/jats:italic>) are associated with pemphigus vulgaris in the Slovak population.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> DNA samples were obtained from 34\u00a0pemphigus vulgaris patients and 140 healthy controls of Slovak origin. Cytokine gene SNPs were determined using the polymerase chain reaction with sequence\u2010specific primers (PCR\u2010SSP) method.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We found a weak association between pemphigus vulgaris and polymorphic variants in <jats:italic>TNF\u2010\u03b1<\/jats:italic> and <jats:italic>IL\u201010<\/jats:italic> genes only, with haplotypes TNF\u2010\u03b1\u2013308G\/\u2013238G and IL\u201010 \u20131082A\/\u2013819C\/\u2013592C being significantly overrepresented in pemphigus vulgaris patients (TNF\u2010\u03b1 GG: 94.12% vs. 82.86%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0216; IL\u201010 ACC: 44.12% vs. 30.00%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0309).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our preliminary results suggest that certain <jats:italic>TNF\u2010\u03b1<\/jats:italic> and <jats:italic>IL\u201010<\/jats:italic> gene polymorphisms might contribute to genetic susceptibility to pemphigus vulgaris; however, their overall impact on disease development will be rather limited.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2009.03260.x","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T13:13:30Z","timestamp":1239196410000},"page":"65-68","source":"Crossref","is-referenced-by-count":29,"title":["<i>TNF\u2010\u03b1<\/i> and <i>IL\u201010<\/i> gene polymorphisms show a weak association with pemphigus vulgaris in the Slovak population"],"prefix":"10.1111","volume":"24","author":[{"given":"J","family":"Javor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Chmurova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Parnicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ferencik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Grosse\u2010Wilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Buc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Svecova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12,7]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2006.00523.x"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.09.003"},{"key":"e_1_2_3_4_2","first-page":"383","article-title":"Cytokines 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