{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:04:54Z","timestamp":1761512694274},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T00:00:00Z","timestamp":1244678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Behcet's disease (BD) is a chronic, inflammatory, multisystem vasculitic disorder. There is no reliable laboratory marker that indicates disease activity. Neopterin is an immunological marker of cellular immune activation, which is secreted by monocytes\/macrophages as a result of interferon\u2010gamma (IFN\u2010\u03b3) secretion by activated T lymphocytes.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> We aimed to investigate serum and urine neopterin levels in BD patients.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Forty\u2010five patients who were diagnosed according to the criteria of the International Study Group for BD and 45 age\u2010 and sex\u2010matched healthy controls were enrolled in the study. Disease activity was considered by clinical findings. Serum and urine neopterin levels and serum IFN\u2010\u03b3 levels were measured.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The mean values of serum and urine neopterin levels were 12.68\u00a0\u00b1\u00a04.87\u00a0nmol\/L and 167.53\u00a0\u00b1\u00a0148.73\u00a0\u00b5mol\/mol creatinine, respectively, in BD patients (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.000 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008, respectively), which were statistically significantly different from the control group. However, there was no significant statistical difference between serum and urine neopterin levels of the clinically active and inactive patients. It was also found that the mean value of serum IFN\u2010\u03b3 levels was higher in healthy controls than in BD patients (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.000).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> We conclude that serum and urinary neopterin measurement can not be used as a reliable laboratory marker as the BD patients\u2019 serum and urinary neopterin levels do not increase in the active stage even though these levels increase when compared to healthy controls.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2009.03334.x","type":"journal-article","created":{"date-parts":[[2009,6,12]],"date-time":"2009-06-12T10:43:34Z","timestamp":1244803414000},"page":"1414-1418","source":"Crossref","is-referenced-by-count":4,"title":["Is there any relationship between serum and urine neopterin and serum interferon\u2010\u03b3 levels in the activity of Behcet's disease?"],"prefix":"10.1111","volume":"23","author":[{"given":"I","family":"Erturan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PY","family":"Basak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AM","family":"Ceyhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VB","family":"Akkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(99)00013-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01893.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(86)80084-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8077.2004.00074.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.2001.00358.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000281071"},{"key":"e_1_2_6_8_2","first-page":"471","article-title":"Clinical significance of serum and urinary neopterin levels in patients with various liver diseases","volume":"87","author":"Daito K","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080412"},{"key":"e_1_2_6_10_2","first-page":"6","article-title":"Serum neopterin levels in patients with replicative and non\u2010replicative HBV carriers","volume":"31","author":"Kaleli \u0130","year":"2006","journal-title":"BMC Infect Dis"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02713657"},{"key":"e_1_2_6_12_2","first-page":"326","article-title":"Serum neopterin levels in Beh\u00e7et's syndrome","volume":"19","author":"Keser G","year":"2000","journal-title":"Clin Rheumatol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.8.728"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.118338"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1093\/clinchem\/35.7.1467","article-title":"Neopterin measured in serum and tissue culture supernates by a competitive enzyme\u2010linked immunosorbent assay","volume":"35","author":"Barak M","year":"1989","journal-title":"Clin Chem"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2423(08)60182-1"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(02)00400-9"},{"key":"e_1_2_6_18_2","unstructured":"Neopterin ELISA user manuel (RE 59321). 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