{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:07:19Z","timestamp":1761743239424},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T00:00:00Z","timestamp":1244505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Beh\u00e7et's disease (BD) is known to be associated with human leucocyte antigen (HLA)\u2010B*51 in many ethnic groups. However, the association of HLA class II gene with BD has been described to be different according to different countries and regions.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> This study aims to investigate the association between polymorphism of HLA\u2010DRB1 alleles and BD.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Forty patients with BD and 100 healthy controls were typed for HLA\u2010DRB1 alleles by the LABType<jats:sup>TM<\/jats:sup> SSO method.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The frequency of HLA\u2010DRB1*14 was significantly higher in BD patients than in controls (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05), while the frequency of HLA\u2010DRB1*15 was markedly lower in BD patients (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05). Regarding clinical manifestations, the frequency of HLA\u2010DRB1*15 was significantly decreased in BD patients with genital ulcerations compared with controls (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05); the frequency of HLA\u2010DRB1*14 was significantly increased in BD patients with erythema nodosum\u2013like lesions and in BD patients with folliculitis\u2010like lesions when compared to controls (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05, respectively). Moreover, the frequency of HLA\u2010DRB1*14 was significantly increased in BD patients under 20\u00a0years of age at the onset of disease (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.01), while the frequency of HLA\u2010DRB1*15 was significantly decreased in them (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05), compared with controls.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The results suggested that HLA\u2010DRB1 alleles might play an important role in the onset and clinical manifestations of BD.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2009.03335.x","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T04:14:00Z","timestamp":1244520840000},"page":"1419-1422","source":"Crossref","is-referenced-by-count":8,"title":["Study on association between polymorphism of HLA\u2010DRB1 alleles and Beh\u00e7et's 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