{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:02:19Z","timestamp":1790319739286,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T00:00:00Z","timestamp":1247443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2010,1]]},"abstract":"Abstract<\/jats:title>\n \n Background\u2002<\/jats:bold>\n Ultraviolet B (UVB) is a well\u2010known modality in increasing skin pigmentation through a variety of proposed mechanisms. Prostaglandin release is one of these mechanisms. Prostaglandin F\n 2\u03b1<\/jats:sub>\n (PGF\n 2\u03b1<\/jats:sub>\n ) analogues, which are used to control ocular hypertension, were reported to induce periocular skin hyperpigmentation.\n <\/jats:p>\n \n Objectives\u2002<\/jats:bold>\n This study aims to evaluate the local effect of three prostaglandin F\n 2\u03b1<\/jats:sub>\n analogues, namely Latanoprost, Bimatoprost and Travoprost on skin pigmentation. Assessment of the role of combination with narrow band UVB (NB\u2010UVB) to each of these drugs is evaluated as well.\n <\/jats:p>\n \n Methods\u2002<\/jats:bold>\n This study involved 18 female adult wild guinea pigs with patchy white and red\/brown fur. The hair was shaved from four red\/brown areas on the dorsal skin of each animal. In two areas of each animal, one of the above\u2010mentioned drugs was applied alone and in conjunction with NB\u2010UVB. In the other two areas, the vehicle was applied alone and in conjunction with NB\u2010UVB exposure. Skin biopsies from each area were done at the start of the study and 4 weeks after, and stained with haematoxylin and eosin (H&E) and Masson\u2010Fontana (MF) stains. Clinical and histopathological changes were evaluated.\n <\/jats:p>\n \n Results\u2002<\/jats:bold>\n Increased pigmentation was found in all areas with PGF\n 2\u03b1<\/jats:sub>\n analogues with and without NB\u2010UVB. However, the former group had more effect both clinically and histopathologically.\n <\/jats:p>\n \n Conclusion\u2002<\/jats:bold>\n PGF\n 2\u03b1<\/jats:sub>\n analogues are promising drugs in inducing skin pigmentation. This effect can be enhanced with NB\u2010UVB exposure.\n <\/jats:p>","DOI":"10.1111\/j.1468-3083.2009.03346.x","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T06:37:10Z","timestamp":1247467030000},"page":"28-31","source":"Crossref","is-referenced-by-count":26,"title":["Skin pigmentation after NB\u2010UVB and three analogues of prostaglandin F\n 2\u03b1<\/sub>\n in guinea pigs: a comparative study"],"prefix":"10.1111","volume":"24","author":[{"given":"TS","family":"Anbar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TS","family":"El\u2010Ammawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fawzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70168-1"},{"key":"e_1_2_6_3_2","first-page":"328","article-title":"Ultraviolet light: a hazard to children","volume":"104","author":"Etzel RA","year":"1999","journal-title":"Newsl Am Acad Pediatr"},{"issue":"11","key":"e_1_2_6_4_2","first-page":"1022","article-title":"Phototherapy with UV\u2010B in vitiligo","volume":"65","author":"K\u00f6ster W","year":"1990","journal-title":"Z Hautkr"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890480045006"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90465-2"},{"issue":"1","key":"e_1_2_6_7_2","first-page":"82","article-title":"311\u00a0nm UVB lamps in the treatment of psoriasis with the Ingram regimen","volume":"69","author":"Karvonen J","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70076-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12873337"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01612.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08923.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A178"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00327-2"},{"key":"e_1_2_6_14_2","first-page":"614","article-title":"Latanoprost and periocular skin color changes","volume":"119","author":"Wand M","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.11.1541"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","unstructured":"Protocol of hematoxylin and eosin staining of tissue sections.Rosenlab Website.http:\/\/www.bcm.edu\/rosenlab\/protocols.htmlaccessed July 2008.","DOI":"10.1101\/pdb.prot4986"},{"key":"e_1_2_6_17_2","first-page":"57","article-title":"The Masson\u2010Fontana method for melanin","volume":"158","author":"Masson P.","year":"1914","journal-title":"C R Acad Sci"},{"key":"e_1_2_6_18_2","first-page":"147","volume-title":"Vitiligo and Psoralen","author":"El\u2010Mofty AM","year":"1968"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70149-2"},{"issue":"5","key":"e_1_2_6_20_2","first-page":"577","article-title":"UV triggers the release of keratinocytes\u2010derived prostaglandins which stimulate melanin synthesis: inhibitory effect of anti\u2010inflammatory drugs","volume":"17","author":"Duval C","year":"2004","journal-title":"Pigment Cell Res"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2003.00126.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2009.03346.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2009.03346.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T08:50:39Z","timestamp":1698915039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2009.03346.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,7]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1111\/j.1468-3083.2009.03346.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2009.03346.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,7]]}}}