{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:13:18Z","timestamp":1791036798526,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T00:00:00Z","timestamp":1256256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Although rosacea is a common disease, the cause of disease is still a mystery \u2013\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection, genetic predisposition, climatic factors, and detrimental habits are implicated as triggers of rosacea.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    The aim of current study is to evaluate several suspected risk factors coincidently.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    Patients with rosacea from a dermatology clinic and skin\u2010healthy controls from an randomly selected employees' population enrolled the study. Skin status were evaluated by one and same dermatologist. Participants were queried for age, gender, sun\u2010reactive skin type, and detrimental habits using a questionnaire; blood samples for detecting\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    serostatus were collected.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Totally 145 skin\u2010healthy controls and 172 subjects either with flushing episodes or established rosacea included the study. In multivariate analysis, rosacea patients had significantly higher chance to have photosensitive skin types (OR 1.75; 95% CI 1.01\u20133.04;\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.05), positive family history to rosacea (OR 4.31; 95% CI 2.34\u20137.92;\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.0001) or previous smoking status (OR 2.01; 95% CI 1.07\u20133.80;\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.05) comparing with skin\u2010healthy controls. There were no statistically significant differences either in gender,\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    serostatus, caffeine intake, alcohol consumption, occupational environment, or education level between rosacea patients and controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    Rosacea is foremost associated with familial predisposition. There is no association between\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection and rosacea in current study.\n                  <\/jats:p>","DOI":"10.1111\/j.1468-3083.2009.03472.x","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T06:13:57Z","timestamp":1256278437000},"page":"565-571","source":"Crossref","is-referenced-by-count":157,"title":["Risk factors associated with 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