{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T20:19:52Z","timestamp":1788121192300,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T00:00:00Z","timestamp":1258588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    To examine if host baseline factors and week 24 mycology results are associated with mycological and clinical cure in patients with onychomycosis treated with oral terbinafine.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design\u2002<\/jats:bold>\n                    Open pilot study to determine prognostic factors in the treatment of onychomycosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting\u2002<\/jats:bold>\n                    Outpatient dermatology clinic.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients\u2002<\/jats:bold>\n                    A total of 199 patients from the Icelandic arm of a trial comparing continuous terbinafine with intermittent terbinafine in onychomycosis were recruited for additional observation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Main outcome measures\u2002<\/jats:bold>\n                    Mycological, clinical and complete cure of the target toenail 72\u2003weeks after treatment was initiated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Patients with matrix involvement or slow nail growth were less likely to reach mycological, clinical and complete cure. Lateral involvement affected complete and mycological cure rates negatively. Patients with a dermatophytoma were less likely to reach mycological cure. Patients with a history of prior infection, men and older patients were less likely to reach clinical cure. Positive culture at 24\u2003weeks affected mycological and clinical cure at 72\u2003weeks negatively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Limitations\u2002<\/jats:bold>\n                    Only patients treated with terbinafine were considered.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions\u2002<\/jats:bold>\n                    Several host\u2010related factors at baseline and positive culture at 24\u2003weeks had negative effects on cure of onychomycosis 72\u2003weeks after treatment was initiated. This finding merits a large study on prognostic outcome factors in onychomycosis.\n                  <\/jats:p>","DOI":"10.1111\/j.1468-3083.2009.03487.x","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T21:43:46Z","timestamp":1258667026000},"page":"679-684","source":"Crossref","is-referenced-by-count":55,"title":["Prognostic factors for cure following treatment of onychomycosis"],"prefix":"10.1111","volume":"24","author":[{"given":"B","family":"Sigurgeirsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.104794"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.18.2133"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00005.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02741.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155502762064665"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199958020-00005"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7190.1031"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.3.353"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630500504713"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01308.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.05035.x"},{"key":"e_1_2_7_13_2","first-page":"633","article-title":"Onychomycosis: predisposed populations and some predictors of suboptimal response to oral antifungal agents","volume":"9","author":"Gupta AK","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.07.011"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01543.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2340\/00015555768283","article-title":"Lateral edge nail involvement indicates poor prognosis for treating onychomycosis with the new systemic antifungals","volume":"76","author":"Baran R","year":"1996","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.149.s65.5.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02050.x"},{"issue":"60","key":"e_1_2_7_19_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2133.2001.00045.x","article-title":"Topical amorolfine for 15\u2003months combined with 12\u2003weeks of oral terbinafine, a cost\u2010effective treatment for onychomycosis","volume":"145","author":"Baran R","year":"2001","journal-title":"Br J Dermatol"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-87-12-546"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2009.03487.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2009.03487.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T19:24:33Z","timestamp":1697311473000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2009.03487.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,5]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1111\/j.1468-3083.2009.03487.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2009.03487.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.5065956.5000054","asserted-by":"object"}]},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,5]]}}}