{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:03:34Z","timestamp":1784322214105,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T00:00:00Z","timestamp":1266364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold>Idiopathic guttate hypomelanosis (IGH) is a common pigmentary disorder, the aetiology and pathogenesis of which are largely unknown. The appearance of IGH\u2010like lesions during phototherapy has been reported previously in only one patient.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold>To describe the clinical and histological features of phototherapy\u2010induced IGH\u2010like lesions, their relation to ultraviolet dosimetry and the course of this eruption in patients with mycosis fungoides (MF).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>The files of all patients with MF who underwent phototherapy in our centre from 1992 to 2008 were searched to identify those in whom IGH\u2010like lesions appeared during treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Among 87 patients with early\u2010stage MF who underwent phototherapy, seven acquired IGH\u2010like lesions during monotherapy with narrow\u2010band ultraviolet B (NB\u2010UVB; four patients) or psoralen and ultraviolet A (PUVA; three patients). All but one had a light complexion. The lesions appeared in areas exposed to ultraviolet light, and not exclusively on the skin previously involved by the disease. The mean number of exposures until appearance of the lesions was 92 for NB\u2010UVB and 137 for PUVA. Biopsy study showed a decreased number of melanocytes. Phototherapy was discontinued in four patients, of whom three showed a partial or complete disappearance of the IGH\u2010lesions. The other three patients are still receiving phototherapy, with no change in their IGH\u2010like lesions.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Phototherapy may induce an eruption bearing similar clinical and histopathological features to IGH. The eruption is rare, appears to emerge only after prolonged therapy and seems to be reversible upon discontinuation of phototherapy. IGH\u2010like eruption should be added to the list of side\u2010effects of phototherapy.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2010.03571.x","type":"journal-article","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T09:44:59Z","timestamp":1266399899000},"page":"1026-1030","source":"Crossref","is-referenced-by-count":17,"title":["Idiopathic guttate hypomelanosis\u2010like lesions in patients with mycosis fungoides: a new adverse effect of phototherapy"],"prefix":"10.1111","volume":"24","author":[{"given":"R","family":"Friedland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Feinmesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fenig\u2010Nakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Hodak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1966.01600200040005"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70003-6"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2340\/0001555562301306","article-title":"On the nature of idiopathic guttate hypomelanosis","volume":"62","author":"Wilson PD","year":"1982","journal-title":"Acta Derm Venerol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987100"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2003.01642.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04530.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06877.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03851.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1365-4362.1997.tb01156.x","article-title":"Vitiligo following the resolution of psoriatic plaques during PUVA therapy","volume":"36","author":"Halcin C","year":"1997","journal-title":"Int J Dermatol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5070\/D34ZD5429J","article-title":"Mycosis fungoides with depigmentation secondary to treatment","volume":"13","author":"Firoz B","year":"2007","journal-title":"Dermatol Online J"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06634.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02170.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2005.00171.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1987.tb04904.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246208"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01761.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12493267"},{"key":"e_1_2_5_19_2","article-title":"Activated T cells may stimulate epidermal hyperplasia in mycosis fungoides","volume":"98","author":"Hodak E","year":"1992","journal-title":"J Invest Dermatol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199510000-00004"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00907-1"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800644"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70219-8"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00596.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2010.03571.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2010.03571.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T02:37:08Z","timestamp":1711247828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2010.03571.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,2]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1111\/j.1468-3083.2010.03571.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2010.03571.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,2]]}}}