{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T08:01:22Z","timestamp":1794643282464,"version":"4.9.1"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Familial lichen sclerosus (LS) has been described in only 37 families. We feel that the association is under\u2010reported.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives\u2002<\/jats:bold>\n                    To determine the percentage of patients with LS who have a positive family history.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method\u2002<\/jats:bold>\n                    A large observational\u2010cohort study of a total of 1052 females at vulval clinics within a University Hospital with a diagnosis of LS of the vulva (clinical diagnosis was confirmed in 80% of cases by histology). Patients were questioned as to family history of LS or balanitis xerotica obliterans; male circumcision for medical reasons; vulval cancer; and routine medical and family history. The outcome was the presence or absence of personal or family history of LS, autoimmune disorder or vulval cancer.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    In total 1052 patients were investigated. Of these, 126 (12%) had a positive family history of LS. These patients belonged to 95 families. Vulval cancer was significantly increased in those with a family history of LS compared with those without (4.1% vs. 1.2%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.05). There was more associated autoimmune disease in familial LS than in sporadic LS, although this was not statistically significant. (7% vs. 5%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&gt;\u20030.2).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    Our data from a large cohort of patients with LS provide evidence of an increased risk for family members to develop LS. This indicates a likely genetic component in the aetiology of LS.\n                  <\/jats:p>","DOI":"10.1111\/j.1468-3083.2010.03572.x","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T04:38:16Z","timestamp":1267072696000},"page":"1031-1034","source":"Crossref","is-referenced-by-count":144,"title":["The high rate of familial lichen sclerosus suggests a genetic contribution: an observational cohort 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