{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:25:34Z","timestamp":1787793934675,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T00:00:00Z","timestamp":1293580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Aimed at the reduction of post\u2010treatment relapse of severe acne, the cumulative dose of oral isotretinoin should be \u2265120\u2003mg\/kg. However, data on the appropriate oral isotretinoin treatment regimen in mild and moderate acne are lacking.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> The purpose of this study was to determine the efficacy of an isotretinoin\u2010sparing protocol in inducing permanent remission of mild and moderate acne.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In this open, prospective, non\u2010comparative study, 150 patients affected with mild\u2010to\u2010moderate acne were treated with isotretinoin until complete recovery and for a further month of treatment, independent of the total cumulative dose reached. Patients then underwent a 1\u2010year maintenance therapy with adapalene 0.1% cream. Patients were followed up for a further year, without any treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 139 patients completed the study. Overall, patients received a mean of 80.92\u2003mg\/kg cumulative dose of isotretinoin. In the 2\u2010year follow\u2010up, relapse only appeared in 13 patients (9.35%).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Comparing our findings with published data, this isotretinoin\u2010sparing regimen was shown to be effective in inducing stable remission and preventing acne relapses in patients with mild\u2010to\u2010moderate acne. Low\u2010cumulative dose regimens may potentially lead to a lower incidence of side\u2010effects and to lower costs than higher doses.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2010.03933.x","type":"journal-article","created":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T09:30:33Z","timestamp":1293615033000},"page":"1094-1098","source":"Crossref","is-referenced-by-count":49,"title":["Low\u2010cumulative dose isotretinoin treatment in mild\u2010to\u2010moderate acne: efficacy in achieving stable remission"],"prefix":"10.1111","volume":"25","author":[{"given":"A.","family":"Borghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Minghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Giari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Virgili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bettoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000182270"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80252-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.002"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.3.2.119"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb04020.x"},{"key":"e_1_2_5_8_2","volume-title":"Acne \u2013 Diagnosis and Management","author":"Cunliffe W","year":"2001"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb11850.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02321.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03626.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.11.1061"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01784.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0777-2"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.03022.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0353.2004.03739.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000249320"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000248038"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb11849.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247322"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.3.376"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00651.x"},{"key":"e_1_2_5_23_2","first-page":"369","article-title":"Isotretinoin in acne vulgaris: a prospective analysis of 160 cases from Kuwait","volume":"4","author":"Al\u2010Mutairi N","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02284.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000090658"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08250.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2010.03933.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2010.03933.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T16:24:28Z","timestamp":1697387068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2010.03933.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,29]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1111\/j.1468-3083.2010.03933.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2010.03933.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,29]]}}}