{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:35:20Z","timestamp":1762623320457},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T00:00:00Z","timestamp":1299196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Despite the incidence of <jats:italic>in situ<\/jats:italic> melanoma is continuously rising; few studies have investigated its clinical and diagnostic features.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To investigate clinical and diagnostic features of <jats:italic>in situ<\/jats:italic> melanoma compared to superficial spreading melanoma (SSM).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> This is a hospital based, case\u2010control study. Ninety consecutive patients with an <jats:italic>in situ<\/jats:italic> melanoma and 90 age and gender matched patients with SSM were enrolled. Main outcome measures were differences in clinical signs that aroused suspicion of <jats:italic>in situ<\/jats:italic> melanoma, detection modalities (self\u2010detection vs. incidental detection by a physician), factors conditioning time between first noticing the suspect lesions and the physician visit.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Median diameter of <jats:italic>in situ<\/jats:italic> melanoma was smaller than SSM (7.5 vs. 9.0\u2003mm, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.024), and 47.8% of <jats:italic>in situ<\/jats:italic> melanomas were smaller than 6\u2003mm, in contrast to 25.6% of SSM (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.002). <jats:italic>In situ<\/jats:italic> melanoma was mainly detected by a dermatologist (Odds Ratio 2.95 <jats:italic>P<\/jats:italic>\u2003=\u20030.018), and in patients with more than 10 melanocytic naevi (Odds Ratio 3.12, <jats:italic>P<\/jats:italic>\u2003=\u20030.008). Clinical factors independently associated to early request of dermatological consultation were age older than 45\u2003years (Odds ratio 3.47, <jats:italic>P<\/jats:italic>\u2003=\u20030.002) and location of lesion in a difficult observation skin site (Odds ratio 4.20, <jats:italic>P<\/jats:italic>\u2003=\u20030.001), but not Breslow\u2019s thickness.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our findings show that <jats:italic>in situ<\/jats:italic> melanoma and SSM share similar clinical characteristics and early warning signs. However, <jats:italic>in situ<\/jats:italic> melanoma is smaller in size than SSM. This may have important implications for early diagnosis and prevention strategies.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04015.x","type":"journal-article","created":{"date-parts":[[2011,3,6]],"date-time":"2011-03-06T01:55:43Z","timestamp":1299376543000},"page":"153-158","source":"Crossref","is-referenced-by-count":11,"title":["Clinical and diagnostic features of <i>in situ<\/i> melanoma and superficial spreading melanoma: a hospital based study"],"prefix":"10.1111","volume":"26","author":[{"given":"P.","family":"Rosina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Tessari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.V.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Girolomoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.423"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-005-3637-4"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.12.015"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.032"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2008.09.002"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.12.1638"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.10.1375"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000520)89:3<271::AID-IJC10>3.0.CO;2-7"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01628.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.03.008"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2007.02.024"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02199.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000520)89:3<280::AID-IJC11>3.0.CO;2-2"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03196.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.5.607"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200208000-00012"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.22.2771"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.1.103-a"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2007.15"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.6.723"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.7640"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960301)77:5<888::AID-CNCR12>3.0.CO;2-#"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199912000-00007"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089160409000125"},{"key":"e_1_2_5_26_2","first-page":"1122","volume-title":"s. 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