{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:34:12Z","timestamp":1773844452979,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T00:00:00Z","timestamp":1302048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Sentinel lymph node (SLN) status is the most important prognostic factor for subjects with primary melanoma thicker than 1\u2003mm.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> We focused our study on patients with disease progression after negative SLN biopsy (SLNB), with the aim of elucidating their clinical and histopathological characteristics, outcome and real incidence of false negative.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A total of 688 melanoma patients who underwent SLNB (1 May 1998\u201331 December 2008) were analysed; all patients had Breslow &gt;1\u2003mm or Breslow &lt;1\u2003mm and at least one of the following features: regression, ulceration and\/or Clark level IV\u2013V.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Progression developed in 114 of 503 negative SLN patients (22.7%); the first metastatic site was regional in 64% and distant in 36% of these cases. Thirty\u2010nine patients had nodal metastases in the SLN basin as first site of progression. High\u2010risk melanomas (<jats:italic>P\u2003<\/jats:italic>=\u20030.001) and elderly patients (<jats:italic>P\u2003<\/jats:italic>=\u20030.0005) had an increased probability of progression. Women with a higher median age and lower limbs primary melanoma developed mainly regional skin metastases, while an increased probability of distant metastases was demonstrated in patients with primary on the trunk and axillary SLN (<jats:italic>P\u2003<\/jats:italic>=\u20030.003, <jats:italic>P\u2003<\/jats:italic>=\u20030.001 respectively). Age at diagnosis, Breslow thickness and regression showed a prognostic relevance in univariate and multivariate analyses on disease\u2010free survival and overall survival.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Even if SLN status remains the most important prognostic factor for melanoma patients, progressive disease after a negative SLNB is a relatively frequent event. However, in our opinion, only a part of negative SLNB patients with metastatic spreading should be considered as false negative (7.75%).<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04055.x","type":"journal-article","created":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T04:46:44Z","timestamp":1302065204000},"page":"242-248","source":"Crossref","is-referenced-by-count":20,"title":["Disease progression in melanoma patients with negative sentinel lymph node: does false\u2010negative specimens entirely account for this phenomenon?"],"prefix":"10.1111","volume":"26","author":[{"given":"P.","family":"Savoia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Fava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Caliendo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Osella\u2010Abate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ribero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Quaglino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Macrip\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.G.","family":"Bernengo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420040034005"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.4.381"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.11.912"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.9.865"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9066-0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e32832166b7"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0540-3"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198412000-00015"},{"key":"e_1_2_5_11_2","first-page":"311","article-title":"[Cutaneous melanoma at the Turin Melanoma Center. 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