{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:57:15Z","timestamp":1790740635518,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T00:00:00Z","timestamp":1302048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Preclinical data and reports of adverse skin reactions in patients treated with dipeptidyl peptidase\u2010IV inhibitors (gliptins) have increased awareness towards skin\u2010targeting side\u2010effects of these anti\u2010hyperglycaemic drugs. Bullous pemphigoid (BP), sometimes drug\u2010induced, is the most commonly acquired autoimmune blistering dermatosis in western countries, typically a disease of the elderly people with significant morbidity and excess mortality.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To report the development of BP in five diabetics under gliptin (4 vildagliptin, 1 sitagliptin) plus metformin in fixed\u2010dose drug combinations.<\/jats:p><jats:p><jats:bold>Case reports\u2002<\/jats:bold> From March to August 2010 six out of nine newly diagnosed BP patients in our Department were type 2 diabetics. Five of them were on gliptin plus metformin (three different trade preparations) for 2\u201313\u2003months prior to BP onset. In all cases BP was controlled after withdrawal of the suspected medication and relatively mild therapeutic interventions. In two cases the eliciting role of the preceding treatment is supported by evidence at the level \u2018probable\/likely\u2019 according to the WHO\u2010UMC algorithm.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> This is the first report of drug\u2010induced BP as a group adverse event of the gliptins plus metformin combination therapy for glycaemia control in type 2 diabetes mellitus patients.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04062.x","type":"journal-article","created":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T04:47:26Z","timestamp":1302065246000},"page":"249-253","source":"Crossref","is-referenced-by-count":125,"title":["Drug\u2010induced bullous pemphigoid in diabetes mellitus patients receiving dipeptidyl peptidase\u2010IV inhibitors plus metformin"],"prefix":"10.1111","volume":"26","author":[{"given":"K.","family":"Skandalis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Spirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gaitanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tsartsarakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.D.","family":"Bassukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.48"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2008.01.006"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2741\/2850"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2006.02.007"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.188"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.06.022"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08515.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.02.017"},{"key":"e_1_2_5_10_2","first-page":"431","volume-title":"Dermatology","author":"Borradori L","year":"2008"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a180"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.301"},{"key":"e_1_2_5_13_2","unstructured":"McDonaghM PetersonK ThakurtaSG DanaT.Drug class review on fixed dose combination drug products for the treatment of type 2 diabetes and hyperlipidemia. 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