{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:02:07Z","timestamp":1768910527361,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T00:00:00Z","timestamp":1302825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Botulinum toxin A (BTX\u2010A) is an effective and safe treatment modality for primary axillary hyperhidrosis. However, some patients experience considerable pain during injections.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Dilution of botulinum toxin A in lidocaine vs. in normal saline for the treatment of primary axillary hyperhidrosis: a double\u2010blind, randomized, comparative preliminary study.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> The aim of this study was to compare the efficacy, safety and pain tolerance of lidocaine\u2010diluted BTX\u2010A vs. saline\u2010diluted BTX\u2010A for the treatment of axillary hyperhidrosis.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Eight patients were injected with 50\u2003U of BTX\u2010A diluted in 0.5\u2003mL of saline and 1\u2003mL of 2% lidocaine into one axilla and 50\u2003U of BTX\u2010A diluted in 1.5\u2003mL of saline into the other axilla in a randomized fashion. The pain associated with the injections were self\u2010assessed by the subjects using a 100\u2010mm visual analogue scale (VAS).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Lidocaine\u2010diluted BTX\u2010A and saline\u2010diluted BTX\u2010A were similarly effective regarding the reduction in sweat production, the onset of sweat cessation and the duration of hypo\/anhidrosis. Nevertheless, the pain VAS score during the injections was significantly lower in the axilla treated with lidocaine\u2010diluted BTX\u2010A than the one treated with saline\u2010diluted toxin.<\/jats:p><jats:p><jats:bold>Limitations\u2002<\/jats:bold> Preliminary study due to relatively small sample size.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Botulinum toxin A diluted in lidocaine causes significantly less pain than BTX\u2010A diluted in saline, whereas it is is equally effective and safe as the latter one in treating axillary hyperhidrosis. Therefore, we suggest that lidocaine\u2010diluted BTX\u2010A may be a better treatment option for the patients with primary axillary hyperhidrosis.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04066.x","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T08:03:32Z","timestamp":1302854612000},"page":"314-318","source":"Crossref","is-referenced-by-count":30,"title":["Dilution of botulinum toxin A in lidocaine vs. in normal saline for the treatment of primary axillary hyperhidrosis: a double\u2010blind, randomized, comparative preliminary study"],"prefix":"10.1111","volume":"26","author":[{"given":"A.T.","family":"G\u00fcle\u00e7","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70081-5"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.3.301"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.01.009"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00839205"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.03.016"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5001"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07760.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06317.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7313.596"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000238338.61631.e0"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32191.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5347"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.01855.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000139563.51598.75"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.2340\/00015555-0465","article-title":"Cooling by frozen gel pack as pain relief during treatment of axillary hyperhidrosis with botulinum toxin A injections","volume":"88","author":"Skiveren J","year":"2008","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)64616-8"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07691.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02085-1"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.10.1255"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.5070\/D348Q9S83P"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.01252.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32331.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1520\/JFS2004196"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2011.04066.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2011.04066.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:36:49Z","timestamp":1697369809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2011.04066.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,15]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1468-3083.2011.04066.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04066.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,15]]}}}