{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:09:30Z","timestamp":1774951770908,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Melasma treatment remains challenging despite various laser systems available, because of potential side\u2010effects and high recurrence rates.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> Non\u2010ablative fractionated photothermolysis (FP) is a promising therapeutic method, long\u2010time results comparing treated vs. non\u2010treated site are lacking.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A total of 14 patients were treated with FP in a split\u2010face mode with standardized adjustments in three sessions (weeks 0, 3\u20134, 6\u20138, follow\u2010up: 26\u201328). At each consultation, improvement was evaluated by patients and physicians. Objective assessment was performed using digital photographs and the pigment imaging tool SIAscope<jats:sup>\u00ae<\/jats:sup>.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Melasma improvement was registered in 83% and 75% of the cases 26\u201328\u2003weeks after the first treatment based on two evaluations: by patient and by physician, respectively. Digital photography and SIAscope<jats:sup>\u00ae<\/jats:sup> revealed improvement in 54% and 85% after the first, 61% and 85% after the second, 41% and 58% after the third treatment, accordingly, mostly due to reduction of the outline sharpness. Patients with lighter skin complexions revealed significant improvement ranged from slight to moderate (<jats:italic>P<\/jats:italic>\u2003=\u20030.03). Postinflammatory hyperpigmentation occurred in two cases with skin types III and IV.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Non\u2010ablative FP can be considered as a valuable treatment option with short\u2010term improvement in terms of mild reduction and softening the edges of melasma in patients with skin types I\/II, if prior topical therapies failed. Treatment of patients with skin types III+ should be critically questioned.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04086.x","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T06:02:31Z","timestamp":1303884151000},"page":"423-430","source":"Crossref","is-referenced-by-count":16,"title":["Split\u2010face study of melasma patients treated with non\u2010ablative fractionated photothermolysis 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