{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:18:41Z","timestamp":1792167521198,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,5,4]],"date-time":"2011-05-04T00:00:00Z","timestamp":1304467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> There are a few case reports in literature that isotretinoin treatment may alter sleep architecture. Also studies in mice suggest a role of retinoids in the contribution of delta oscillations to the sleep electroencephalography.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> The aim of this study was to investigate the effect of isotretinoin treatment on sleep architecture using polysomnography (PSG).<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> Twelve severe acne vulgaris patients without any psychiatric and sleep disorders were treated with 0.5\u2003mg\/kg of isotretinoin. Clinician\u2010administered acne questionnaire, psychiatric examination, Epworth sleepiness scale and PSG recordings were performed after the first month of treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Sleep efficiency was increased from 83.5% (62.8\u201389.0%, quartiles) to 89.5% (81.5\u201393.5%, quartiles; <jats:italic>P<\/jats:italic>\u2003=\u20030.036) and sleep latency decreased from 18.0\u2003min (11.1\u201336.3, quartiles) to 15.5\u2003min (9.3\u201319.0, quartiles; <jats:italic>P<\/jats:italic>\u2003=\u20030.023) following 1\u2010month isotretinoin treatment. There were no significant changes in other sleep parameters of PSG and scores of Epworth sleepiness scale.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> This study suggests that isotretinoin treatment slightly improves night\u2010time sleep without any effects on sleep stages and daytime sleepiness.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04095.x","type":"journal-article","created":{"date-parts":[[2011,5,4]],"date-time":"2011-05-04T08:20:37Z","timestamp":1304497237000},"page":"778-781","source":"Crossref","is-referenced-by-count":13,"title":["Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study"],"prefix":"10.1111","volume":"26","author":[{"given":"S","family":"Ismailogullari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ferahbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Baydemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Utas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246134"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.048"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113719"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00066.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117623"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.02.077"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04171.x"},{"key":"e_1_2_5_9_2","first-page":"821","article-title":"Hypersomnia associated with isotretinoin in a patient with recurrent major depressive disorder and acne vulgaris","volume":"27","author":"Shehi GM","year":"2004","journal-title":"Sleep"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01711.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160698"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_5_13_2","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","author":"Iber C","year":"2007"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5352.863"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.65010050.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.3181\/0703-RM-83"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0370166"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/09546630903341978"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000920202"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2011.04095.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2011.04095.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:21:14Z","timestamp":1697368874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2011.04095.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,4]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1468-3083.2011.04095.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04095.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,4]]}}}