{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T06:39:20Z","timestamp":1769323160972,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T00:00:00Z","timestamp":1305244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Psoriasis vulgaris could be associated with the filaggrin null genotype since certain known susceptibility loci for psoriasis are shared with susceptibility loci for atopic dermatitis. Furthermore, filaggrin expression is lowered in psoriatic skin lesions but normally expressed in uninvolved skin. So far five relatively small patient\u2010based case\u2010control studies have rejected a possible association between psoriasis and the two most prevalent filaggrin null mutations, 2282del4 and R501X.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To reinvestigate a possible association between psoriasis and filaggrin null mutation status by using cross\u2010sectional general population questionnaire data. Also, to perform a meta\u2010analysis including published studies that investigated the relation between filaggrin gene mutations R501X and 2282del4, respectively, and psoriasis vulgaris.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Between June 2006 and May 2008, a cross\u2010sectional study was performed in the general population in Copenhagen. A random sample of 7931 subjects aged 18\u201369\u2003years was invited to participate in a general health examination including a questionnaire and 3471 (43.7%) participated. A total of 3335 (96.1%) individuals were filaggrin genotyped for the 2282del4 and R501X mutations. A meta\u2010analysis was undertaken to investigate the relation between filaggrin gene mutations and psoriasis vulgaris.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The prevalence of self\u2010reported psoriasis was 6.7% among the 3240 respondents. The prevalence of the R501X and 2282del4 filaggrin null genotypes was 9.3% in subjects who reported psoriasis and 8.0% in subjects who did not report psoriasis (OR\u2003=\u20031.28; 95% CI\u2003=\u20030.74\u20131.89; <jats:italic>P\u2003<\/jats:italic>=\u20030.78). The meta\u2010analysis found no association between the filaggrin null genotypes R501X and 2282del4 and psoriasis (OR\u2003=\u20031.04; 95% CI\u2003=\u20030.81\u20131.35).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Psoriasis was not associated with the R501X and 2282del4 filaggrin null genotypes in a general population study and in a meta\u2010analysis on published studies.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04107.x","type":"journal-article","created":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T06:48:45Z","timestamp":1305269325000},"page":"782-784","source":"Crossref","is-referenced-by-count":14,"title":["The filaggrin null genotypes R501X and 2282del4 seem not to be associated with psoriasis: results from general population study and meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"JP","family":"Thyssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JD","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BC","family":"Carlsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Linneberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Meldgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PB","family":"Szecsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Stender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Menn\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2340\/0001555561344346","article-title":"The prevalence of psoriasis in Denmark","volume":"61","author":"Brandrup F","year":"1981","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700720"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2433"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh094"},{"key":"e_1_2_6_6_2","first-page":"157","article-title":"Expression of epidermal N\u2010methyl\u2010D\u2010aspartate receptors (NMDAR1) depends on formation of the granular layer \u2013 analysis in diseases with parakeratotic cornification","volume":"296","author":"Fischer M","year":"2004","journal-title":"Arch Dermatol Res"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0821-2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109365"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700771"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700817"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09157.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09708.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.10.062"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09314.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2011.04107.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2011.04107.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:21:17Z","timestamp":1697368877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2011.04107.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,13]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1468-3083.2011.04107.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04107.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,13]]}}}