{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:59:53Z","timestamp":1792684793387,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T00:00:00Z","timestamp":1308787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> In analogy with melanoma\u2010associated leucoderma, halo naevi may trigger in some patients the development of additional depigmentations which are in distribution, extent and prognosis not in accordance with classic vitiligo.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> The aim of this study was to support the hypothesis that in a subset of halo naevi patients vitiligo\u2010like lesions develop directly linked to the halo phenomenon.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Forty\u2010one patients with halo naevi were examined for the development of depigmentations not corresponding to typical vitiligo lesions.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We identified a subset of five halo naevi patients with additional subtle depigmentations. After the occurrence of multiple halo naevi, they developed leucoderma that showed a different disease pattern than vitiligo (variable asymmetric distribution, limited extent and lack of progression). Moreover, the characteristics of these halo naevi patients with associated leucoderma were different from classic vitiligo patients (high number of halo naevi, absence of family history for vitiligo and absence of autoimmune diseases) and the timing of occurrence of the leucoderma suggested a direct relation with the halo phenomenon.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In this article, we describe in a limited subset of patients with multiple halo naevi discrete depigmentations at distance from halo naevi which may result from a temporary autoimmune process directly linked to the halo phenomenon. This finding illustrates the collateral damage resulting from skin immunosurveillance and may have clinical consequences as the evolution pattern in this subset of patients is less progressive compared with vitiligo. We present clinical data that support this hypothesis and suggest to call it \u2018halo naevi\u2010associated leucoderma\u2019.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04160.x","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T09:20:59Z","timestamp":1308820859000},"page":"755-761","source":"Crossref","is-referenced-by-count":22,"title":["Halo naevi with associated vitiligo\u2010like depigmentations: pathogenetic hypothesis"],"prefix":"10.1111","volume":"26","author":[{"given":"N.","family":"van Geel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Speeckaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Mollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"De Keyser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"De Schepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Brochez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,23]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"647","volume-title":"The Pigmentary System. 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