{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:15:15Z","timestamp":1793200515027,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Peeling skin diseases (PSD) refer to a group of rare autosomal recessive dermatosis which are characterized by spontaneous, continual peeling of the skin. Three different clinical pictures can be distinguished: Inflammatory PSD also referred to as peeling skin syndrome (PSS) type B, non\u2010inflammatory PSD also referred to as PSS type A, and localized forms i.e. acral type PSS.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To characterize the clinical and histopathological features of PSD in Turkey.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We retrospectively reviewed the medical records and clinical photographs of patients who were given diagnosis of PSD and conducted histopathological evaluation of skin biopsies to identify the site of cleavage. Also we evaluated the cases including age, gender, age onset, clinical and histological findings, family history, associated disorders and PSD type.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Twenty\u2010one patients with PSD were seen at Gulhane School of Medicine in Ankara between the years 1994 and 2010 in this retrospective study. All patients were men. Their ages were between 20 and 26\u2003years (22.44\u2003\u00b1\u20032.30, Mean age\u2003\u00b1\u2003SD). Of the patients, eight cases (40%) were type A, eight cases (40%) were type B, and five cases (20%) were acral type PSS. Eleven cases (52%) had parental consanguinity. Keratoderma, cheilitis, keratosis pilaris, melanonichia, clubbing, hyperhidrosis, onychodystrophy were observed in eight cases as an accompanying disorder.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In this case series, PSD occurred rarely and also showed generally mild course of disease in Turkey and most likely related to consanguineous of marriages. Future investigations on PSD will contribute to our progressing alternative targets for pathogenesis\u2010based therapy.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04166.x","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T14:52:35Z","timestamp":1309445555000},"page":"844-848","source":"Crossref","is-referenced-by-count":13,"title":["Peeling skin diseases: 21 cases from Turkey and a review of the 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