{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:38:19Z","timestamp":1779233899268,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,7,9]],"date-time":"2011-07-09T00:00:00Z","timestamp":1310169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction\u2002<\/jats:bold> Bowen disease (BD) or squamous cell carcinoma (SCC) <jats:italic>in situ<\/jats:italic> affects both skin and mucous membranes and has the potential to progress to invasive SCC. Photodynamic therapy (PDT) has been approved recently for the treatment of BD. Some studies have demonstrated its efficacy and good cosmetic outcome.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To assess the efficacy of PDT in the treatment of BD.<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> We carried out an observational, retrospective and descriptive study. A total of 47 patients with 51 lesions of BD were included. All the lesions were confirmed with previous cutaneous biopsy. All patients were treated with the standard protocol. Topical methyl\u2010aminolaevulinic acid was occluded during 3 h and followed by illumination with red\u2010light (630\u2003nm, 38\u2003J\/cm<jats:sup>2<\/jats:sup>, 7.5\u2003min). Clinical and fluorescence photographs images were taken before each session. All patients received two sessions one week apart. Clinical response was classified in partial or complete response. Fluorescence response was classified in negative, intermediate or intense. The follow\u2010up period and the adverse events observed including pain were also collected.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 20 men and 27 women with a mean age of 75.57\u2003years old were treated with PDT. Lesions were most frequently located in the lower limbs. Globally, 76.09% of the lesions achieved complete response after 2 sessions with a medium follow\u2010up of 16.61\u2003months. Fluorescence of the lesions disappeared when clinical response was achieved, but not always. The most common adverse effect was an immediate burning sensation. All lesions showed an excellent cosmetic result.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Photodynamic therapy is an effective treatment for BD in terms of both clinical remission and cosmetic results, with good tolerance and minimal adverse effects.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04175.x","type":"journal-article","created":{"date-parts":[[2011,7,9]],"date-time":"2011-07-09T04:23:28Z","timestamp":1310185408000},"page":"868-874","source":"Crossref","is-referenced-by-count":50,"title":["Effectiveness of photodynamic therapy in Bowen\u2019s disease: an observational and descriptive study in 51 lesions"],"prefix":"10.1111","volume":"26","author":[{"given":"M.","family":"Truchuelo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fern\u00e1ndez\u2010Guarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Fleta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Alc\u00e1ntara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ja\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07610.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000245196.73224.cb"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05033.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08593.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03430.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.7.790"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70208-W"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1996.tb04011.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.6.729"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-1076.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.12.033"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03441.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02720.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03664.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.54013.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07833.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.01.055"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04085.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00333.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.01825.x"},{"key":"e_1_2_5_22_2","first-page":"319","article-title":"Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma","volume":"137","author":"Morton CA","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.03.028"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2006.09.009"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04719.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03773.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2005.10.027"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06830.x"},{"key":"e_1_2_5_29_2","first-page":"30","article-title":"Comparison of PpIX accumulation and destruction during methyl\u2010aminolevulinate photodynamic therapy (MAL\u2010PDT) of skin tumours located at acral and non\u2010acral sites","volume":"8","author":"Tyrell JS","year":"2011","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_30_2","volume-title":"Prevalencia del C\u00e1ncer cut\u00e1neo no melanoma y factores de riesgo asociados","author":"Ortega\u2010Bravo M","year":"2003"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.12.1524"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(79)90152-1"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70003-C"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-59410-6_28"},{"key":"e_1_2_5_35_2","first-page":"779","article-title":"Retrospective, descriptive, observational study of treatment of multiple actinic keratoses with topical methyl aminolevulinate and red light: results in clinical practice and correlation with fluorescence imaging","volume":"99","author":"Fernandez\u2010Guarino M","year":"2008","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_5_36_2","first-page":"30","article-title":"EDUCACION MEDICA CONTINUA: diagn\u00f3stico por fluorescencia o fotodin\u00e1mico. Fotograf\u00eda con luz ultravioleta","volume":"14","author":"Harto AL","year":"2007","journal-title":"Rev Chilena Dermatol"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03687.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2011.04175.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2011.04175.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T08:31:52Z","timestamp":1697358712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2011.04175.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,9]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1468-3083.2011.04175.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04175.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,9]]}}}