{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:47:26Z","timestamp":1778273246711,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T00:00:00Z","timestamp":1311638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstracts<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Infantile seborrhoeic dermatitis (ISD) is a common skin lesion in infants. There may be differences in recommendation for treatment of ISD.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To compare the efficacy of moisturizer containing licochalcone vs. 1% hydrocortisone for the treatment of ISD.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> This was a randomized, prospective, split\u2010side, double\u2010blind study that was conducted in 75 infants between the age of 2\u2003weeks and 1\u2003year. Patients with a clinical diagnosis of ISD were treated twice daily, simultaneously with either moisturizer containing 0.025% licochalcone or 1% hydrocortisone on opposite sides of the lesion. The scoring system was used to assess the severity of the rash by the presence of erythema, scale and crusts. The lesions on each side were evaluated on day 0, 3\u20134, 6\u20137 and 14.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 72 patients completed the study. The moisturizer containing licochalcone group had a higher clearing rate (42%) compared to 1% hydrocortisone group (32%) (<jats:italic>P<\/jats:italic>\u2003=\u20030.03) on day 3\u20134. Both products were equally effective in the treatment at day 6\u20137 and 14 (<jats:italic>P<\/jats:italic>\u2003=\u20030.45 and 1, respectively). By the end of the second week, the cure rate of the moisturizer containing 0.025% licochalcone and 1% hydrocortisone group was 90% and 92%, respectively.<\/jats:p><jats:p><jats:bold>Limitations\u2002<\/jats:bold> The small sample size was a study limitation.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Moisturizer containing 0.025% licochalcone had higher cure rate compared to 1% hydrocortisone for the treatment of ISD at day 3\u20134. However, by the end of the first week, this difference was no longer significant.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04187.x","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T18:20:43Z","timestamp":1311704443000},"page":"894-897","source":"Crossref","is-referenced-by-count":22,"title":["Randomized, double\u2010blind, split\u2010side comparison study of moisturizer containing licochalcone vs. 1% hydrocortisone in the treatment of infantile seborrhoeic dermatitis"],"prefix":"10.1111","volume":"26","author":[{"given":"S.","family":"Wananukul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Chatproedprai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Charutragulchai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,26]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1356","article-title":"Survey of common cutaneous lesion in healthy infants at the well baby clinic","volume":"91","author":"Chatproedprai S","year":"2008","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.3.318"},{"key":"e_1_2_6_4_2","first-page":"297","article-title":"Infantile seborrheic dermatitis","volume":"77","author":"Elish D","year":"2006","journal-title":"Cutis"},{"key":"e_1_2_6_5_2","first-page":"101","article-title":"Malassezia furfur in seborrheic dermatitis","volume":"23","author":"Wananukul S","year":"2005","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1997.tb00680.x"},{"key":"e_1_2_6_7_2","first-page":"334","article-title":"Infantile seborrheic dermatitis and pityrosporum ovale","volume":"21","author":"Broberg A","year":"1994","journal-title":"J Dermatol"},{"key":"e_1_2_6_8_2","first-page":"P901","volume-title":"Pediatric Dermatology","author":"Hogan PA","year":"2011"},{"key":"e_1_2_6_9_2","first-page":"S68","article-title":"Comparative study of 2% ketoconazole cream and 1% hydrocortisone cream in the treatment of infantile seborrheic dermatitis","volume":"87","author":"Wananukul S","year":"2004","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247855"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1996.tb01425.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1998.tb01378.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-006-0654-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/10915810701351228"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2006.00261.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630310014369"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03845.x"},{"key":"e_1_2_6_18_2","first-page":"125","article-title":"Seborrheic dermatitis: an overview","volume":"74","author":"Schwartz RA","year":"2006","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb04878.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(01)00202-8"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.57.12.0017"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1226-1230.2002"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2011.04187.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2011.04187.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T08:31:35Z","timestamp":1697358695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2011.04187.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,26]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1468-3083.2011.04187.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04187.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,26]]}}}