{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:15:45Z","timestamp":1775470545925,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T00:00:00Z","timestamp":1315958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols. Moreover, vitamin A is well\u2010known in dermatology for its actions, including the ultraviolet radiation absorbing property.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> In view of experimental evidence for the photoprotective properties of these antioxidants, we evaluated in 30 patients with photosensitivity, the prophylactic efficacy of a new topical agent, containing tocopherols 10% and tocotrienols 0.3%, compared with retinol, simple vehicle and untreated areas.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> After determination of the minimal UVB erythema dose (MED), two areas of 2\u2003\u00d7\u20032\u2003cm were selected on the buttocks of each subject, one of which was treated with the antioxidant formulation whereas the other field did not undergo any treatment. Therefore, both areas were irradiated with a twofold MED. As further controls, other two similar areas, selected on the forearm of 15 patients, were photo\u2010irradiated similarly, 30 min after application of the simple vehicle to a field and of vitamin A in the same vehicle to the other. Reactions (erythema\/oedema\/itch\/vesciculation) assessment was carried out assigning scores indicative of their intensity; then, mean values +DS of scores were calculated.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The pre\u2010treatment with the vitamin E formulation highly protects against photosensitivity, and all reactions to irradiation were significantly lower in the areas treated with the topical vitamin E formulation compared to those treated with the simple vehicle or vitamin A.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The use of a new topical formulation containing significant concentrations of tocotrienols and tocopherols represents a promising strategy to reduce the photo\u2010induced skin damage.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04219.x","type":"journal-article","created":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T14:41:48Z","timestamp":1316011308000},"page":"1449-1453","source":"Crossref","is-referenced-by-count":25,"title":["Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)"],"prefix":"10.1111","volume":"26","author":[{"given":"V.F.","family":"Pedrelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Lauriola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.D.","family":"Pigatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,14]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"VertuaniS ZiosiP ManfrediniS PedrelliV PigattoP.Antioxidant and photoprotective activity of a formulatiotion based on tocopherols and tocotrienols. 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