{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:03:50Z","timestamp":1777356230070,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T00:00:00Z","timestamp":1316995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Vitiligo has been found to be associated with different HLA antigens in different ethnic groups. In our previous genome\u2010wide association study (GWAS), we identified independent association signal of rs9468925 (<jats:italic>P<\/jats:italic>\u2003=\u20032.21\u2003\u00d7\u200310<jats:sup>\u221233<\/jats:sup>, OR\u2003=\u20030.74) within HLA\u2010C\u2010HLA\u2010B region.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To explore the association between rs9468925 polymorphism within MHC and the clinical features of generalized vitiligo.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The study, using 5566 cases and 6462 controls from previous GWA study investigated the single and combined (GA\u2003+\u2003GG) genotypic distribution of rs9468925 in subsets of vitiligo patients having different clinical features. We performed a QTL analysis (quantitative trait locus) for age of onset with genotype of rs9468925.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The GA\u2003+\u2003GG genotypic distribution of SNP rs9468925 tested with an additive model was found to be significantly different in subgroups of patients of &gt;20 vs. &lt;20\u2003years old (genotypic <jats:italic>P<\/jats:italic>\u2003=\u20032.57\u2003\u00d7\u200310<jats:sup>\u22124<\/jats:sup>, combined <jats:italic>P<\/jats:italic>\u2003=\u20033.0\u2003\u00d7\u200310<jats:sup>\u22123<\/jats:sup>, OR\u2003=\u20030.77, 95% CI: 0.64\u20130.92), and in patients with different clinical subtypes of vitiligo (genotypic <jats:italic>P<\/jats:italic>\u2003=\u20030.03, combined <jats:italic>P<\/jats:italic>\u2003=\u20035.0\u2003\u00d7\u200310<jats:sup>\u22123<\/jats:sup>). However, there was no statistical significance for familial history, halo nevi involvement and autoimmune disease involvement.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Allele G of rs9468925 on HLA\u2010C\u2010HLA\u2010B may be associated with a higher risk of vitiligo. Our study showed a significant genotypic variation between patients with age of onset \u226420\u2003years and age of onset &gt;20\u2003years. Obvious clinical differences of generalized vitiligo related to genotypic variation found in the Chinese Han population were confirmed in this study.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04259.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T01:10:08Z","timestamp":1317172208000},"page":"1137-1141","source":"Crossref","is-referenced-by-count":6,"title":["A single nucleotide polymorphism rs9468925 of MHC region is associated with clinical features of generalized vitiligo in Chinese Han population"],"prefix":"10.1111","volume":"26","author":[{"given":"Jianlan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HuaYang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XianBo","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PeiGuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiangDan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XueJun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920010791526105"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256371"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370020107"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.3.310"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804388"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/9780470760116.ch6","volume-title":"Vitiligo","author":"Hann SK","year":"2000"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.044"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.603"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00355.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1991.tb02984.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/archderm.1990.01670250062009","article-title":"Vitiligo is associated with HLA\u2010DR4 in black patients. 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