{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:52:35Z","timestamp":1790805155487,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T00:00:00Z","timestamp":1318204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Topical or systemic antiviral drugs reduce the duration of herpes simplex virus 1 (HSV\u20101) recurrences but may not alleviate functional symptoms.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives\u2002<\/jats:bold>\n                    To assess the efficacy and safety of CS20 (Acura 24\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ) protective barrier gel versus topical aciclovir and placebo in resolving functional symptoms in HSV\u20101 labial recurrences.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    A prospective, randomized, single\u2010centre, assessor\u2010blinded study of CS20 versus topical aciclovir or placebo. The primary endpoint was the total score of four herpes\u2010related functional symptoms (pain, burning, itching, and tingling sensations), evaluated by visual analogue scale (VAS). Secondary endpoints encompassed objective skin changes (oedema, crusting and erythema), evaluated by specific clinical scores.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    In a study of 106 patients, compared with placebo, a significant improvement in total functional symptom score was observed after 1 day of treatment in the CS20 group, but only after 7 days of treatment in the topical aciclovir group. Burning sensations were significantly reduced by CS20 compared with aciclovir (Days 1\u20132) or placebo (Days 1\u20137). Compared to placebo, CS20 significantly reduced pain intensity on Days 1\u20136. CS20 induced significant and early improvements in the clinical scores for oedema and crusting compared with placebo. Time to cure was similar for CS20 and aciclovir. The treatments were well tolerated and adverse events were comparable in the three treatment groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Limitations\u2002<\/jats:bold>\n                    The single\u2010centre and single\u2010blind design of the study and the preselection of patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    CS20 showed superior effectiveness against functional symptoms (pain and burning) associated with HSV\u20101 labial recurrences and was similar to aciclovir for time to cure.\n                  <\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04269.x","type":"journal-article","created":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T12:37:05Z","timestamp":1318250225000},"page":"1240-1246","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of the efficacy and safety of a CS20\n                    <sup>\u00ae<\/sup>\n                    protective barrier gel containing OGT compared with topical aciclovir and placebo on functional and objective symptoms of labial herpes recurrences: a randomized clinical trial"],"prefix":"10.1111","volume":"26","author":[{"given":"A.","family":"Khemis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Duteil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.C.","family":"Coudert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Dereure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Ortonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,10]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"64","article-title":"Treatment of herpes simplex labialis","volume":"9","author":"Spruance SL","year":"2002","journal-title":"Herpes"},{"key":"e_1_2_7_3_2","first-page":"79","volume-title":"Dermatologie et V\u00e9n\u00e9r\u00e9ologie","author":"Beylot C","year":"1991"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02473.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2002.0366"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1870-1874.2002"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6487.7"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6379.1699"},{"key":"e_1_2_7_9_2","first-page":"1184","article-title":"Randomized clinical study comparing Compeed\u00ae cold sore patch to acyclovir cream 5% in the treatment of herpes simplex labialis","volume":"22","author":"Karlsmark T","year":"2008","journal-title":"JEADV"},{"key":"e_1_2_7_10_2","first-page":"437","article-title":"Efficacy of a new oral lubricant solution in the management of psychotropic drug\u2010induced xerostomia: a randomized clinical trial","volume":"27","author":"Mouly SJ","year":"2007","journal-title":"J Clin Pharmacol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200724110-00007"},{"key":"e_1_2_7_12_2","first-page":"17","article-title":"Presentation of a gel designed for patients with removable dentures","volume":"18","author":"Lodter JP","year":"2003","journal-title":"Prosthet Altern"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199447010-00009"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D285"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.11.1137"},{"key":"e_1_2_7_16_2","first-page":"S12","article-title":"Management of recurrent oral herpes simplex infections","volume":"103","author":"Woo SB","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.7.2238-2243.2002"},{"key":"e_1_2_7_18_2","first-page":"576","article-title":"Clinical inquiries. 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