{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:32:07Z","timestamp":1759530727453},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T00:00:00Z","timestamp":1316995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Recurrent aphthous ulceration (RAU) is considered to be an acute inflammatory disease of unknown pathogenesis. Apoptosis may represent an important event in the control of inflammation.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> The aim of this study was to investigate apoptosis process in RAU using immunohistochemistry.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We studied the expression and location of p53, bcl\u20102 and bax in ulcerated lesions clinically diagnosed as RAU (<jats:italic>n\u2003<\/jats:italic>=\u200312) and compared it with that of oral clinically normal mucosa (<jats:italic>n\u2003<\/jats:italic>=\u20036) and of other inflammatory chronic disease such as oral fibrous inflammatory hyperplasia (FIH; <jats:italic>n\u2003<\/jats:italic>=\u200318).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Significant statistically differences (<jats:italic>n<\/jats:italic>\u2003&lt;\u20030.05) in p53 expression were noticed in RAU when compared with normal mucosa. No significant statistically differences (<jats:italic>P\u2003<\/jats:italic>&gt;\u20030.05) were noticed between FIH and RAU. Bcl\u20102 and bax did not show remarkable differences between groups.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Taken together, the data suggest that RAU induces p53 immunoexpression. Therefore, the protein might be related to the aetiopathogenesis of the ulcerated oral lesions.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04274.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T01:10:08Z","timestamp":1317172208000},"page":"1247-1251","source":"Crossref","is-referenced-by-count":10,"title":["Expression of apoptosis regulatory proteins p53, bcl\u20102 and bax in recurrent aphthous ulceration"],"prefix":"10.1111","volume":"26","author":[{"given":"J.F.N.","family":"Pinto Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.T.","family":"Fujiyama Oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Ribeiro Paiotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.S.","family":"Miki Ihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.A.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,26]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"95","article-title":"Recurrent aphthous stomatitis","volume":"31","author":"Ship JA","year":"2000","journal-title":"Quintessence Int"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090030401"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1989.tb00727.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.7.827"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00625-6"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(03)00090-3"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.124.1.1"},{"key":"e_1_2_5_9_2","first-page":"5124","article-title":"Impairment of function in aging neutrophils is associated with apoptosis","volume":"150","author":"Whyte MKB","year":"1993","journal-title":"J lmmuno"},{"key":"e_1_2_5_10_2","first-page":"3331","article-title":"Semiautomated assessment of loss of heterozygosity and replication error in tumors","volume":"56","author":"Canzian F","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203285"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(93)90209-Z"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401243"},{"key":"e_1_2_5_14_2","first-page":"231","article-title":"Programmed cell death via mitochondria: different modes of dying","volume":"70","author":"Bras M","year":"2005","journal-title":"Biochemistry"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00987.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-364932-4.50010-1"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01324.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/ijom.2002.0446"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199804)184:4<360::AID-PATH1263>3.0.CO;2-H"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198301063080107"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.10.1375"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00665.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(96)04258-9"},{"key":"e_1_2_5_24_2","unstructured":"BalassianoKZ.Comparative Study of Expression Immunohistochemistry in bcl2 p53 Caspase3 and ki67 in Hyperplasiainflammatory Fibrous Cheilitis Actin\u2010Cell Carcinomas Squamous the Lower Lip. 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