{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:24:54Z","timestamp":1790375094425,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T00:00:00Z","timestamp":1318204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Acne vulgaris is a multifactorial disease of the skin. Several studies have shown that elevated levels of serum insulin\u2010like growth factor\u2010I (IGF\u2010I) correlate with overproduction of sebum and acne. Recently functional relationship between IGF\u2010I (CA) polymorphism and circulating IGF\u2010I levels in adults has been reported.<\/jats:p><jats:p><jats:bold>Aims\u2002<\/jats:bold> The aim of our study was to investigate for the first time whether IGF\u2010I (CA) polymorphism might be involved in the pathogenesis of acne or not.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We included 115 acne patients and 117 healthy subjects to the study. The clinical grade of acne was assessed based on the Global Acne Grading System. Participants were questioned about diabetes mellitus, PCOS and other systemic disease. We searched for the IGF\u2010I (CA) 19 polymorphism in this study. The IGF\u2010I (CA) 19 polymorphism was performed by polymerase chain reaction.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We categorized the IGF\u2010I (CA) 19 polymorphism area into three groups as lower than 192\u2003bp, 192\u2013194\u2003bp and higher than 194\u2003bp. We found that the frequency of genotype IGF\u20101 (CA) 19 gene was significantly different between control and acne patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.0002). A significant association between IGF\u2010I (CA) genotypes and severity of acne was found (<jats:italic>P<\/jats:italic>\u2003=\u20030.015). No significant difference was found between male and female patients (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our results suggest that IGF\u2010I (CA) 19 polymorphism may contribute to a predisposition to acne in Turkish patients.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04299.x","type":"journal-article","created":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T16:48:20Z","timestamp":1318265300000},"page":"254-257","source":"Crossref","is-referenced-by-count":35,"title":["Insulin\u2010like growth factor\u2010I gene polymorphism in acne vulgaris"],"prefix":"10.1111","volume":"27","author":[{"given":"L.","family":"Tasli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kacar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ayada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Coban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Akcilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ergin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00175.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1995.tb03381.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.3.333"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08764.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.4274\/turkderm.44.69"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701155"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-009-9729-6"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02078.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1480171"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2008.10.009"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2133.2009.09618.x","article-title":"Short\u2010term isotretinoin treatment decreases insulin\u2010like growth factor\u20101 and insulin\u2010like growth factor binding protein\u20103 levels: does isotretinoin affect growth hormone physiology?","volume":"162","author":"Karadag AS","year":"2010","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.563"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi294"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1093\/clinchem\/45.8.1384","article-title":"Serum insulin\u2010like growth factors and insulin\u2010like growth factor\u2010binding proteins: clinical implications","volume":"45","author":"Rosen CJ","year":"1999","journal-title":"Clin Chem"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-007-0241-3"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm190"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2011.04299.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2011.04299.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T11:13:10Z","timestamp":1697368390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2011.04299.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,10]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1468-3083.2011.04299.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04299.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,10]]}}}