{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:19:54Z","timestamp":1770131994643,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T00:00:00Z","timestamp":1318896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Fumarates are approved for the systemic treatment of moderate and severe psoriasis vulgaris in Germany. However, a number of studies and case reports indicate their efficacy in the treatment of further inflammatory skin disorders or granulomatous skin diseases.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To examine the efficacy and safety of fumarates for the treatment of granulomatous and inflammatory skin diseases other than psoriasis vulgaris.<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> The therapeutic efficacy and side\u2010effects of fumarate therapy were analysed retrospectively in patients with granuloma annulare (GA, <jats:italic>n<\/jats:italic>\u2003=\u20034), cutaneous sarcoidosis (SA, <jats:italic>n<\/jats:italic>\u2003=\u20031), lichen planus (LP, <jats:italic>n<\/jats:italic>\u2003=\u20033), pityriasis rubra pilaris (PRP, <jats:italic>n<\/jats:italic>\u2003=\u20031) or chronic discoid lupus erythematosus (CDLE, <jats:italic>n<\/jats:italic>\u2003=\u20031).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Six patients (GA: 3\/4; LP: 2\/3; PRP: 1\/1) showed complete clearance and two patients (GA: 1\/3; SA: 1\/1) had a partial response, and the CDLE patient showed stable disease under a combination therapy with hydroxychloroquine. Side\u2010effects associated with fumarate therapy were seen in seven of ten patients and resolved spontaneously upon dose reduction or discontinuation of the therapy.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> According to this data, fumarates may represent a new approach in the treatment of granulomatous and inflammatory skin diseases other than psoriasis vulgaris. For the first time, the successful treatment of LP and CDLE with fumarates is reported. Side\u2010effects are not limiting in most cases, but can hamper a dose escalation.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04303.x","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T13:36:25Z","timestamp":1318944985000},"page":"1400-1406","source":"Crossref","is-referenced-by-count":19,"title":["Off\u2010label use of fumarate therapy for granulomatous and inflammatory skin diseases other than psoriasis vulgaris: a retrospective study"],"prefix":"10.1111","volume":"26","author":[{"given":"A.","family":"Klein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Coras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Landthaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Babilas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06585.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06762.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-2-15"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.27"},{"key":"e_1_2_5_6_2","first-page":"300","article-title":"Treatment of therapy\u2010resistant Alopecia areata with fumaric acid esters","volume":"11","author":"Venten I","year":"2006","journal-title":"Eur J Med Res"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-4-22"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.364"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.197"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1061-4"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05153.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260916"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01159.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07002.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1747.2003.12605.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700686"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02400.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700996"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000083514"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0647"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.2165\/11530070-000000000-00000"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.9.4781"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.242"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05433.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10171.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C173"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07479_suppl.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017903"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03234.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5070\/D341R194B9","article-title":"Granuloma annulare disseminatum responding to fumaric acid esters","volume":"14","author":"Wollina U","year":"2008","journal-title":"Dermatol Online J"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-004-0728-1"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000074133"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000066434"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-2-5"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050051294"},{"key":"e_1_2_5_36_2","article-title":"Sarkoidose mit kutaner Dissemination: Zwei F\u00e4lle unter Fumars\u00e4uretherapie. 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