{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:51:06Z","timestamp":1767851466467,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T00:00:00Z","timestamp":1319414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Oral lichen planus (OLP) is a chronic inflammatory disease for which the pathogenesis is not fully understood. OLP has autoimmune features and auto immunity has been suggested as a potential cause, whereas WHO has classified OLP as a premalignant condition. Association between chronic inflammation and cancer is known and chronic inflammation is one of the characteristics of OLP. A protein connected to inflammation and suggested to be involved in cancer development is cyclooxygenase\u20102 (COX\u20102) which can be inhibited by microRNA\u201026b (miR\u201026b).<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> The aim was to map levels of COX\u20102 and miR\u201026b in OLP lesions to see if there was any correlation between expression of COX\u20102 and its regulator miR\u201026b in OLP.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In biopsies from 20 OLP patients and 20 age and gender\u2010matched controls laser\u2010 micro dissection of epithelium was performed. Quantitative RT\u2010PCR, immunohistochemistry and Western blot were used in the analysis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Levels of COX\u20102 mRNA were significantly higher while levels of miR\u201026b were significantly lower in OLP lesions compared to controls. Using immunohistochemistry normal oral mucosa samples did not show any expression of COX\u20102 while OLP samples expressed the protein. No COX\u20102 protein was detectable with Western blot.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Increased expression of COX\u20102 and decreased expression of miR\u201026b in OLP suggests both to play a role in OLP. COX\u20102 has been connected to both malignant development and autoimmunity but as malignant development of OLP is quite rare we suggest that the increased levels of COX\u20102 seen here support an autoimmune cause of the disease.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04306.x","type":"journal-article","created":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T07:58:43Z","timestamp":1319443123000},"page":"1415-1419","source":"Crossref","is-referenced-by-count":34,"title":["Increased levels of COX\u20102 in oral lichen planus supports an autoimmune cause of the 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