{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T20:59:34Z","timestamp":1774040374035,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T00:00:00Z","timestamp":1320192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The place of cell\u2010mediated immunity and cytokines in the immunopathogenesis of pemphigus vulgaris (PV) has not been fully established.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To assess the serum levels of pro\u2010inflammatory cytokines, Interleukine\u20106 (IL\u20106) and Interleukine\u20108 (IL\u20108), in PV patients before and after therapy, to evaluate the influence of therapy on the serum cytokine levels.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Sixty\u2010six newly diagnosed PV patients enrolled into the study. The serum levels of IL\u20108 and IL\u20106 were measured in 66 and 64 patients, respectively. According to the extent of skin and mucosal involvement, the patients were divided into two groups namely mild and severe. The serum levels of cytokines were measured using enzyme\u2010linked immunosorbent assay (ELISA) method before and after 4\u2003weeks of prednisolone plus azathioprine therapy.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In 64 patients studied for the serum level of IL\u20106, the median IL\u20106 level was significantly decreased from 1.6 to 0.9\u2003pg\/mL by therapy (<jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030.001). Segregating the patients according to the severity of the disease, the serum level of IL\u20106 did not differ significantly by therapy in patients with a mild disease. However, in patients with a severe disease the median serum level of IL\u20106 decreased significantly from 1.8 to 0.9\u2003pg\/mL after therapy (<jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030.001). No significant changes were found in the IL\u20108 level by treatment.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The significant decrease in the IL\u20106 level after therapy suggests that blocking of IL\u20106 could have therapeutic benefits for the treatment of PV, particularly in severe forms.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04319.x","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T06:35:45Z","timestamp":1320215745000},"page":"387-390","source":"Crossref","is-referenced-by-count":12,"title":["The influence of systemic therapy on the serum levels of IL\u20106 and IL\u20108 in pemphigus vulgaris"],"prefix":"10.1111","volume":"27","author":[{"given":"H.","family":"Mortazavi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Babaeijandaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Akbarzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Amirzargar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Daneshpazhooh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Jalali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Hallaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198205203062001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087104"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2008.07.008"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09629359890875"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00151-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06497.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03677.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02501.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02593.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.1.228"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00027-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1428"},{"key":"e_1_2_6_14_2","first-page":"383","article-title":"Cytokines in the sera of patients with pemphigus vulgaris: interleukin\u20106 and tumour necrosis factor\u2010alpha levels are significantly increased as compared to healthy subjects and correlate with disease activity","volume":"8","author":"D\u2019Auria L","year":"1997","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/875394"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.12.007"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.56.5.559"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018085"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03638.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.03.005"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2011.04319.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2011.04319.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:16:56Z","timestamp":1697343416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2011.04319.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,2]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/j.1468-3083.2011.04319.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04319.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,2]]}}}