{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T21:09:15Z","timestamp":1723842555712},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T00:00:00Z","timestamp":1322092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> It still remains debatable whether peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3) is pro\u2010 or antineoplastic, and its exact role in mycosis fungoides (MF) remains unclear.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> This prospective comparative study aimed to investigate the expression of PPAR\u03b3 in MF and compare it with psoriatics and controls in a trial to deduce its possible role in MF. Also, we tried to clarify the relation between PPAR\u03b3 and Bcl\u20102 in MF.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Twenty MF patients, 20 psoriatic patients and 20 controls were included. All participants underwent a skin biopsy, and immunohistochemical staining for both PPAR\u03b3 and Bcl\u20102 were performed. Western blot analysis was performed for detection of both PPAR\u03b3 and Bcl\u20102.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The mean area per cent of PPAR\u03b3 measured in the MF patients (57.1217\u2003\u00b1\u20039.502417) was significantly higher (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.001) when compared with that of both the psoriatics (2.989\u2003\u00b1\u20031.723) and controls (35.9357\u2003\u00b1\u20038.1789). The mean area per cent of Bcl\u20102 in MF patients (9.3763\u2003\u00b1\u20036.6328) was significantly higher (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.001) than that of both the psoriatics (2.35\u2003\u00b1\u20031.35) and the controls (0.73105\u2003\u00b1\u20030.5302)]. Our results were confirmed using the western blot analysis. We detected a highly significant positive correlation between the PPAR\u03b3 and Bcl\u20102 mean area per cents in all patients. In our MF patients, both parameters were also positively correlated with the age of the patient, duration and stage of MF (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Our data suggest a possible role for PPAR\u03b3 in the pathogenesis of MF possibly through several mechanisms, one of which might be conferring upon the lymphoma cells, a survival advantage at least partially through up regulating Bcl\u20102.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04333.x","type":"journal-article","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T08:37:12Z","timestamp":1322123832000},"page":"1522-1532","source":"Crossref","is-referenced-by-count":1,"title":["Peroxisome proliferator\u2010activated receptor gamma, a possible culprit in mycosis fungoides: an immunohistochemical 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