{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:15:26Z","timestamp":1789823726628,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T00:00:00Z","timestamp":1321833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> There has been no study on antibiotic\u2010resistant <jats:italic>Propionibacterium acnes<\/jats:italic> in Hong Kong.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> We investigated the prevalence and pattern of antibiotic\u2010resistant <jats:italic>P<\/jats:italic>. <jats:italic>acnes<\/jats:italic> and to identify any associated factors for harbouring the resistant strains.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Culture and sensitivity testing of <jats:italic>P. acnes<\/jats:italic> to commonly used antibiotics were performed. Resistance to tetracycline was defined at a minimal inhibitory concentration (MIC) of 2\u2003\u03bcg\/mL or more; erythromycin at an MIC of 0.5\u2003\u03bcg\/mL or more; clindamycin at an MIC of 0.25\u2003\u03bcg\/mL or more according to EUCAST. For breakpoints of doxycycline and minocycline, those with an MIC of 1\u2003\u03bcg\/mL or more were defined as resistant strains.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Among the 111 specimens collected from 111 patients, 86 strains of <jats:italic>P. acnes<\/jats:italic> were recovered, one from each specimen. Twenty\u2010five specimens had no growth. Forty\u2010seven (54.8%) strains were found to be resistant to one or more antibiotics. Forty\u2010six (53.5%), 18 (20.9%), 14 (16.3%), 14(16.3%) and 14 (16.3%) strains were resistant to clindamycin (CL), erythromycin (EM), tetracycline (TET), doxycycline (DOX) and minocycline (MR) respectively. Ten strains (11.6%) had cross resistance between the MLS antibiotics (erythromycin or clindamycin), one strain (1.2%) had cross resistance among the cyclines and 14 strains (16.4%) had cross resistance between the MLS and cycline antibiotics. Binary logistic regression showed an association between MLS antibiotic resistance with an increased age whereas cycline resistance was associated with the duration of treatment.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Antibiotic\u2010resistant <jats:italic>P. acnes<\/jats:italic> is prevalent in Hong Kong. Dermatologists should be more vigilant in prescribing antibiotics for acne patients.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04351.x","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T14:15:40Z","timestamp":1321884940000},"page":"31-36","source":"Crossref","is-referenced-by-count":58,"title":["Antibiotic\u2010resistant <i>Propionibacterium acnes<\/i> among acne patients in a regional skin centre in Hong Kong"],"prefix":"10.1111","volume":"27","author":[{"given":"N.\u2010M.T.","family":"Luk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010C.S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.H.","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.H.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.Y.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Eastel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010K.A.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.\u2010S.N.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u2010S.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.\u2010Y.C.","family":"Siu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010C.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010K.D.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010M.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310016463"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363150-00005"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10375.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.07.001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-16-3-271"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)70005-8"},{"key":"e_1_2_7_8_2","first-page":"21","article-title":"The development of antibiotic resistance in Propionibacterium acnes","volume":"67","author":"Leyden J","year":"2001","journal-title":"Cutis"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04690.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000067822"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05067.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1989.tb01399.x"},{"key":"e_1_2_7_13_2","first-page":"655","article-title":"The development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review","volume":"9","author":"Patel M","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2004.02.002"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08087.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.2340\/0001555559552554","article-title":"Antibiotic sensitivity of comedonal Propionibacterium acnes","volume":"59","author":"Guin JD","year":"1979","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_17_2","first-page":"43","article-title":"Propionibacterium: resistance of acne to antibiotics","volume":"108","author":"Oakley A","year":"1995","journal-title":"N Z Med J"},{"key":"e_1_2_7_18_2","first-page":"1655","article-title":"Antibiotic susceptibility of Propionibacterium acnes; changes in the last 15 years at the Department of Dermatology, Kansai Medical University","volume":"96","author":"Kurokawa I","year":"1986","journal-title":"Nippon Hifuka Gakkai Zasshi"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01109.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017869"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.03956.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.7.1702"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04270.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01109.x"},{"key":"e_1_2_7_25_2","first-page":"885","article-title":"The resistance of Propionibacterium acnes and Staphylococcus epidermidis to cyclines. The Research and Study Group on Acne","volume":"125","author":"Noyon V","year":"1998","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_7_26_2","first-page":"25","article-title":"Antimicrobial susceptibility of Propionibacterium acnes isolated from acne vulgaris","volume":"9","author":"Kurokawa I","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304120-00002"},{"key":"e_1_2_7_28_2","first-page":"22","article-title":"Antibiotic sensitivity of Propionibacterium acnes isolates from patients with acne vulgaris in a tertiary dermatological referral centre in Singapore","volume":"30","author":"Tan HH","year":"2001","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb08270.x"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400060939"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1468-3083.2011.04351.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1468-3083.2011.04351.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T06:46:22Z","timestamp":1697352382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1468-3083.2011.04351.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,21]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.1468-3083.2011.04351.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04351.x","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,21]]}}}