{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:57:50Z","timestamp":1778770670928,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T00:00:00Z","timestamp":1323216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Melanoma is an immunogenic tumour type frequently associated with spontaneous auto\u2010immune manifestations such as spontaneous regression, vitiligo\u2010like reactions or auto\u2010immune retinopathy, which seem to be associated with better prognosis.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> The aim of this prospective study was to evaluate the correlation between spontaneous autoimmunity and survival in patients with stage IV melanoma.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> From 2007 to 2008, 103 patients were studied with antithyroid and antinuclear auto antibody assays performed every 6\u2003months. Any detectable occurrence of a spontaneous self antibody (SpSA) at the upper detection limit, at least for one assay, was considered to be a biological marker of autoimmunity.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Univariate and multivariate analyses confirmed significantly longer survival in the absence of known primary melanoma (<jats:italic>P<\/jats:italic>\u2003=\u20030.044) and in the presence of marker of biologic autoimmunity, independently of previous immunotherapy (<jats:italic>P<\/jats:italic>\u2003=\u20030.045).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> This prospective and comparative study is, to our knowledge, the first to report the frequency of SpSA in stage IV melanoma. Our results suggest that spontaneous autoimmunity, through a rupture of self\u2010tolerance, is a good prognostic factor in a subgroup of patients with stage IV melanoma.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04364.x","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T06:37:46Z","timestamp":1323239866000},"page":"92-96","source":"Crossref","is-referenced-by-count":27,"title":["Metastatic melanoma: spontaneous occurrence of auto antibodies is a good prognosis factor in a prospective 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