{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:21:19Z","timestamp":1783570879983,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> In healthy skin, there is a molecular microenvironment that favours the survival of melanocytes and regulates their function. Keratinocytes synthesize and secrete several cytokines that have stimulatory and inhibitory effects on melanocytes.<\/jats:p><jats:p><jats:bold>Aim of the work\u2002<\/jats:bold> This work was conducted to evaluate the expression of basic fibroblast growth factor (bFGF) and tumour necrosis factor alpha (TNF\u2010\u03b1) mRNA levels in lesional skin of vitiligo, hypopigmented mycosis fungoides and hypopigmented tinea versicolor.<\/jats:p><jats:p><jats:bold>Patients and Methods\u2002<\/jats:bold> Forty eight patients (25 vitiligo, 14 hypopigmented mycosis fungoides, 9 hypopigmented tinea versicolor) and 10 healthy controls were included. A 4\u2003mm punch skin biopsy was taken from lesional skin of patients, and the normal skin of controls for quantitative PCR examination of TNF\u2010\u03b1 and bFGF mRNA.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The level of TNF\u2010\u03b1 mRNA in lesional skin of the three studied disorders was significantly higher than in the control group, while the level of bFGF mRNA was significantly lower in lesional skin of the three diseases than the control skin. A significant inverse correlation was demonstrated between the mRNA levels of the two studied cytokines in vitiligo and hypopigmented MF lesions.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The study\u2019s findings demonstrate that the studied hypopigmented (vitiligo, hypopigmented MF, hypopigmented TV) disorders show similar changes in their cutaneous microenvironment with increased TNF\u2010\u03b1 and decreased bFGF mRNA expression. This cytokine microenvironment change may be implicated in the pigment loss and hence these cytokines may have future therapeutic implications.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04368.x","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T09:53:07Z","timestamp":1323337987000},"page":"103-108","source":"Crossref","is-referenced-by-count":37,"title":["Basic fibroblast growth factor and tumour necrosis factor alpha in vitiligo and other hypopigmented disorders: suggestive possible therapeutic targets"],"prefix":"10.1111","volume":"27","author":[{"given":"H.","family":"Seif El Nasr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.G.","family":"Shaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.T.","family":"Fawzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"El\u2010Hanafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,8]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Dermatology in General Medicine","author":"Jimbo K","year":"1999"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12709595"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640205"},{"key":"e_1_2_5_5_2","volume-title":"Vitiligo: Problems and solutions","author":"Hautmann G","year":"2004"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3130625"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"24675","DOI":"10.1016\/S0021-9258(18)35817-4","article-title":"Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes","volume":"267","author":"Imokawa G","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1997.tb00488.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12460991"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.7.3967"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155500300012918"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.1o049.x"},{"key":"e_1_2_5_13_2","first-page":"725","article-title":"Report of the committee on Staging and Classification of Cutaneous T\u2010cell Lymphoma","volume":"63","author":"Bunn PA","year":"1979","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_5_14_2","first-page":"1","volume-title":"Conducting and Reading Research in Health and Human Performance","author":"Baumgartner AT","year":"1998"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02744.x"},{"key":"e_1_2_5_16_2","first-page":"78","article-title":"Basic Fibroblast growth factor stimulates proliferation and suppresses melanogenesis in cell cultures derived from early zebrafish embryos","volume":"3","author":"Bradford CS","year":"1994","journal-title":"Mol Mar Biol Biotechnol"},{"key":"e_1_2_5_17_2","first-page":"161","article-title":"Effects of bFGF and alpha\u2010MSH on adhesion and migration of human melanocytes in vitro","volume":"35","author":"Zhang XQ","year":"2006","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0161"},{"key":"e_1_2_5_19_2","first-page":"849","article-title":"Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis","volume":"24","author":"Moretti S","year":"2009","journal-title":"Histol Histopathol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00263.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021148601424"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05224.x"},{"key":"e_1_2_5_23_2","first-page":"17","article-title":"Vitiligo vs. hypopigmented mycosis fungoides (histopathological and immunohistochemical study, univariate analysis)","volume":"16","author":"El\u2010Darouti MA","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200204000-00006"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00907-1"},{"key":"e_1_2_5_26_2","first-page":"617","article-title":"Targeting human TNF\u2010\u03b1. 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