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However, conventional PDT for AKs is associated with inconveniently long clinic visits and discomfort during therapy. In this article, we critically review daylight\u2010mediated PDT, which is a simpler and more tolerable treatment procedure for PDT. We review the effective light dose, efficacy and safety, the need for prior application of sunscreen, and potential clinical scope of daylight\u2010PDT. Three randomized controlled studies have shown that daylight\u2010mediated PDT is an effective treatment of thin AKs. Daylight\u2010mediated PDT is nearly pain\u2010free and more convenient for both the clinics and patients. Daylight\u2010mediated PDT is especially suited for patients with large field\u2010cancerized areas, which can easily be exposed to daylight. Further investigations are necessary to determine at which time of the year and in which weather conditions daylight\u2010mediated PDT will be possible in different geographical locations.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04386.x","type":"journal-article","created":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T19:34:01Z","timestamp":1324668841000},"page":"673-679","source":"Crossref","is-referenced-by-count":195,"title":["Daylight photodynamic therapy for actinic keratosis: an international 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