{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:23:17Z","timestamp":1790248997747,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T00:00:00Z","timestamp":1325721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Ultraviolet (UV) exposure results in the production reactive oxygen species. Resveratrol has attracted considerable attentions owing to its natural abundance and multiple biological effects.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To investigate the protective effects of resveratrate against damage to human skin induced by repetitive solar simulator ultraviolet radiation (ssUVR).<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> Fifteen healthy volunteers were enrolled, and six sites on the non\u2010exposed dorsal skin of each volunteer were marked for study. Sites 1\u20134 were exposed to ssUVR at a dosage of 1.5 minimal erythema dose for consecutive 4\u2003days. Immediately after each exposure, one test material (resveratrate\u2003+\u2003antioxidant, antioxidant, resveratrate, vehicle) was applied to one of the four sites. Site 5 and site 6 were marked as positive control site (UVR only) and baseline control site (no treatment, no UVR). <jats:italic>L<\/jats:italic>*<jats:italic>a<\/jats:italic>*<jats:italic>b<\/jats:italic> values were assessed preprocedure and postprocedure. Skin biopsies were taken 24\u2003h after the last irradiation. The specimens were stained to determine the number of sunburn cells and melanin content melanin.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> On resveratrate treated sites, erythema was barely seen with only slight decrease of <jats:italic>L<\/jats:italic> value and insignificant increase of *<jats:italic>a<\/jats:italic> value. Furthermore, resveratrate significantly inhibited sunburn cell formation, and decreased Fontana\u2010Masson staining in skin samples.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Resveratrate exerts protective effects against repetitive ssUVR\u2010induced sunburn and suntan.<\/jats:p>","DOI":"10.1111\/j.1468-3083.2011.04414.x","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T01:05:22Z","timestamp":1325811922000},"page":"345-350","source":"Crossref","is-referenced-by-count":41,"title":["Resveratrate protects human skin from damage due to repetitive ultraviolet 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